To realize nano scale x-ray imaging on a benchtop scale without highly specialized and costly x-ray optical componenets, we are developing an amplified photoresist film that is sensitive to x-ray and electron beam radiation, and can support nanometer scale features. These features are read accurately quantified by a compact atomic force microscopy. We have achieved initial success in a gold amplified E-beam resist system and obtained radiographs of x-ray gratings at 50 nm resolution. Concurrently, we are developing a new way to observe the interaction of x-ray with biological samples by imaging the reactive oxygen species produced by the x-ray beam. This approach is aimed to improve the contrast and specificity of nanometer scale x-ray microscopy of biological samples.
| Wen, Han; Morales Martinez, Alejandro; Miao, Houxun et al. (2018) Correlative Detection of Isolated Single and Multi-Cellular Calcifications in the Internal Elastic Lamina of Human Coronary Artery Samples. Sci Rep 8:10978 |
| Larsen, Thomas C; Gopalakrishnan, Vissagan; Yao, Jianhua et al. (2018) Optimization of a secondary VOI protocol for lung imaging in a clinical CT scanner. J Appl Clin Med Phys 19:271-280 |
| Morales, A G; Stempinski, E S; Xiao, X et al. (2016) Micro-CT scouting for transmission electron microscopy of human tissue specimens. J Microsc 263:113-7 |
| Gomella, Andrew; Martin, Eric W; Lynch, Susanna K et al. (2013) Low dose hard x-ray contact microscopy assisted by a photoelectric conversion layer. AIP Adv 3:42121 |
