Abstract

The Section on Molecular Genetics closed this year and the final two members of the Section, Staff Scientist Dr. David Sandstrom and postdoctoral fellow Elyssa Burg, both moved on to new positions after four months. Both of them concluded their respective research projects and brought them to publication prior to leaving. A paper by Dr. Sandstrom and several co-authors describes evidence that the Drosophila ryanodine receptor is a target of volatile anesthetics and was published in the journal Anesthesiology (Gao et al., 2013, Anesthesiology 118: 587-601). A paper by Dr. Burg and several co-authors characterized the molecular and cellular basis of a simple social behavior in Drosophila (i.e. Resource Independent Local Enhancement) and was published in the journal Genes, Brain and Behavior (Burg et al., 2013, Genes, Brain, and Behavior 12: 338-47). These two papers and the FY2012 Annual Report should be consulted for a summary of the final research conducted by the SOMG.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAMH002228-28
Application #
8745677
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
28
Fiscal Year
2013
Total Cost
$51,541
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Sandstrom, David J (2011) Extracellular protons reduce quantal content and prolong synaptic currents at the Drosophila larval neuromuscular junction. J Neurogenet 25:104-14
Freeman, Amanda; Franciscovich, Amy; Bowers, Mallory et al. (2011) NFAT regulates pre-synaptic development and activity-dependent plasticity in Drosophila. Mol Cell Neurosci 46:535-47
Alone, Debasmita P; Rodriguez, Jason C; Noland, Cameron L et al. (2009) Impact of gene copy number variation on anesthesia in Drosophila melanogaster. Anesthesiology 111:15-24
Campbell, Joseph L; Gu, Qun; Guo, Dongyu et al. (2009) Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. J Neurogenet 23:412-21
Peabody, Nathan C; Pohl, Jascha B; Diao, Fengqiu et al. (2009) Characterization of the decision network for wing expansion in Drosophila using targeted expression of the TRPM8 channel. J Neurosci 29:3343-53
Campbell, Joseph; Gu, Qun; Guo, Dongyu et al. (2009) Genetic Effects in Drosophila on the Potency of Diverse General Anesthetics: A Distinctive Pattern of Altered Sensitivity. J Neurogenet :1-10