Abstract

Further work on the cellular mechanisms underlying neurologic and pscyhiatric disorders is limited by the fact that neurons throughout the brain utilize common mechanisms for critical functions such as synaptic plasticity, whereas specific neural systems are affected in different disorders. A large part of the Laboratory is now working with the Gene Expression Nervous System Atlas (GENSAT) project ( funded by NINDS and NIMH ) to produce transgenic mice with Cre-recombinase under the regulation of promoters to drive expression in specific neuron populations. Our part of this work is to characterize the expression of Cre in the brains of such transgenic lines and to provide such lines to the Mutant Mouse Regional Resource Center (MMRRC) for distribution to the research community ( Gong et al., 2007). In the past year we characterized 200 Cre driver lines of which 60 were added to those made available through the GENSAT project: www.gensat.org/index.html .

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAMH002497-23
Application #
8556907
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
23
Fiscal Year
2012
Total Cost
$1,705,193
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Gerfen, Charles R; Economo, Michael N; Chandrashekar, Jayaram (2018) Long distance projections of cortical pyramidal neurons. J Neurosci Res 96:1467-1475
Economo, Michael N; Viswanathan, Sarada; Tasic, Bosiljka et al. (2018) Distinct descending motor cortex pathways and their roles in movement. Nature 563:79-84
Wang, Lupeng; Rangarajan, Krsna V; Gerfen, Charles R et al. (2018) Activation of Striatal Neurons Causes a Perceptual Decision Bias during Visual Change Detection in Mice. Neuron 97:1369-1381.e5
Jiang, Sunny Zhihong; Xu, Wenqin; Emery, Andrew C et al. (2017) NCS-Rapgef2, the Protein Product of the Neuronal Rapgef2 Gene, Is a Specific Activator of D1 Dopamine Receptor-Dependent ERK Phosphorylation in Mouse Brain. eNeuro 4:
Guo, Zengcai V; Inagaki, Hidehiko K; Daie, Kayvon et al. (2017) Maintenance of persistent activity in a frontal thalamocortical loop. Nature 545:181-186
Wang, Xuhua; Liu, Yuanyuan; Li, Xinjian et al. (2017) Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills. Cell 171:440-455.e14
Wang, Wenting; Li, Chenchen; Chen, Qian et al. (2017) Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism. J Clin Invest 127:1978-1990
Barbera, Giovanni; Liang, Bo; Zhang, Lifeng et al. (2016) Spatially Compact Neural Clusters in the Dorsal Striatum Encode Locomotion Relevant Information. Neuron 92:202-213
Gerfen, Charles R; Sawchenko, Paul E (2016) An anterograde neuroanatomical tracing method that shows the detailed morphology of neurons, their axons and terminals: Immunohistochemical localization of an axonally transported plant lectin, Phaseolus vulgaris-leucoagglutinin (PHA-L). Brain Res 1645:42-5
Crittenden, Jill R; Tillberg, Paul W; Riad, Michael H et al. (2016) Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons. Proc Natl Acad Sci U S A 113:11318-11323

Showing the most recent 10 out of 26 publications