Obsessive-compulsive disorder (OCD) affects 1-2% of children and adolescents, causing significant distress and impairments from the unrelenting obsessional thoughts and compulsive behaviors. A unique subgroup of children with OCD has been identified on the basis of the acuity of their symptom onset. The cohort is identified by the acronym PANS, for Pediatric Acute-onset Neuropsychiatric Syndrome. The syndrome is characterized by the sudden onset of OCD and/or eating disorder, accompanied by at least two of the following seven comorbidities: 1) Anxiety; 2) Emotional lability and/or depression; 3) Irritability, aggression and/or severely oppositional behaviors; 4) Behavioral (developmental) regression; 5) Deterioration in school performance; 6) Sensory or motor abnormalities; 7) Somatic signs and symptoms, including sleep disturbances, enuresis or urinary frequency and others. For a full description, see: Chang K et al. Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): Recommendations from the 2013 PANS Consensus Conference. J Child Adolesc Psychopharmacology 2015. 25(1): p 3-13. Acute-onset obsessive-compulsive disorder has gained the attention of the clinical and scientific communities in recent years, with a number of basic science publications revealing new information about the cause and disease mechanisms affecting children with PANDAS (For a review, please see KA Williams & S Swedo, Brain Res. 2015 Aug 18;1617:144-54. doi: 10.1016/j.brainres.2014.09.071. Epub 2014 Oct 7). Clinical research efforts are also increasing, and Dr. Swedo is currently leading efforts to create a nationwide collaborative PANS/PANDAS clinical research network with the goals of (1) improving recognition, diagnosis, and treatment of acute onset neuropsychiatric syndromes, (2) conducting research which improves understanding of etiologic factors, host vulnerability, and disease mechanisms, and c) increasing awareness and recognition of PANDAS, PANS, and related disorders in order to improve access to care. The clinical description of PANS arose from investigations of a group of children with acute-onset OCD whose symptoms appeared to arise as a consequence of common childhood infections, including Group A streptococcal (GAS) infections (strep throat and Scarlet fever). Children whose symptoms begin or exacerbate following GAS infections may belong to a subgroup of neuropsychiatric disorders identified by the acronym PANDAS (for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections). The postulated etiology for the PANDAS subgroup is that specific strains of Group A streptococci (GAS), in genetically susceptible individuals, elicit the production of cross-reactive antibodies which recognize antigens not only on the GAS cell wall, but also in the host brain tissue, eliciting obsessions, compulsions, tics and other neuropsychiatric symptoms. The cross-reactive antibodies have been shown to correlate with other anti-streptococcal antibodies and also with neuropsychiatric symptom severity, with highest titers seen in children acutely ill with Sydenham chorea or PANDAS symptomatology. Research at NIH and elsewhere has revealed that: the PANDAS subgroup has a specific and identifiable symptom course (marked most notably by the acute, abrupt, overnight onset of symptoms (zero to sixty in less than 24 hours); the cross-reactive antibodies correlate with both GAS infection status and neuropsychiatric symptom severity; passive transfer of the cross-reactive antibodies replicated disease symptoms in animal models; prevention of GAS infections through antibiotic prophylaxis results in prevention of neuropsychiatric symptom exacerbations; and, treatment of acutely ill children with immunomodulatory therapies specifically, intravenous immunoglobulin (IVIG) or plasmapheresis, may produce dramatic reductions in symptom severity. This line of research is unusual, in that it reverses the typical bench to bedside progression and takes clinical observations into the laboratory in search of information about etiopathogenic mechanisms. This approach is yielding exciting results, as serum samples from acutely ill children contain cross-reactive antibodies which target brain antigens, presumably triggering the clinical manifestations. Identification of the antigenic targets may provide new targets for therapeutic interventions. Dr. Swedo, Dr. James Leckman and colleagues at the Yale University Child Study Center, and Dr. Madeleine Cunningham of the University of Oklahoma Health Sciences Center were the joint recipients of an NIH Bench to Bedside award which helped fund a multi-site placebo-controlled trial of intravenous immunoglobulin (IVIG) for severely ill children with PANDAS (Protocol 11-M-0058, NCT 01281969). More than 40 children (3-12 years old) enrolled in the trial and 35 were randomly assigned to receive an infusion of IVIG or placebo. Long-term follow-up of the participants is ongoing, and data are available from baseline, 6 weeks, 3 months, 6 months and 1-3 year evaluations. Most children experienced a significant reduction in PANDAS symptoms over the course of the study, and results suggest that IVIG therapy may be an effective treatment for some children; the manuscript describing study results is currently under review. Current efforts focus on identifying predictors of treatment response, including biological samples being analyzed by Dr. Cunningham, Dr. Kyle Williams (MGH-Harvard), Dr. Mady Hornig (Columbia University) and Dr. Carlos Pardo (Johns Hopkins). We anticipate that the results of their collaborative investigations will further clarify the pathologic role of cross-reactive antibodies in PANDAS and thus identify biomarkers for disease activity and treatment response. More information about the study is available at: http://clinicalstudies.info.nih.gov/cgi/detail.cgi?B_2011-M-0058.html

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24
Fiscal Year
2016
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U.S. National Institute of Mental Health
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Grant, Paul; Farmer, Cristan; Song, Jane et al. (2017) Riluzole Serum Concentration in Pediatric Patients Treated for Obsessive-Compulsive Disorder. J Clin Psychopharmacol 37:713-716
Swedo, Susan E; Frankovich, Jennifer; Murphy, Tanya K (2017) Overview of Treatment of Pediatric Acute-Onset Neuropsychiatric Syndrome. J Child Adolesc Psychopharmacol 27:562-565
Hommer, Rebecca E; Swedo, Susan E (2017) Anorexia and Autoimmunity: Challenging the Etiologic Constructs of Disordered Eating. Pediatrics 140:
Thienemann, Margo; Murphy, Tanya; Leckman, James et al. (2017) Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part I-Psychiatric and Behavioral Interventions. J Child Adolesc Psychopharmacol 27:566-573
Gaughan, Thomas; Buckley, Ashura; Hommer, Rebecca et al. (2016) Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). J Clin Sleep Med 12:1027-32
Williams, Kyle A; Swedo, Susan E; Farmer, Cristan A et al. (2016) Randomized, Controlled Trial of Intravenous Immunoglobulin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections. J Am Acad Child Adolesc Psychiatry 55:860-867.e2
Williams, Kyle A; Swedo, Susan E (2015) Post-infectious autoimmune disorders: Sydenham's chorea, PANDAS and beyond. Brain Res 1617:144-54
Kovacevic, Miro; Grant, Paul; Swedo, Susan E (2015) Use of intravenous immunoglobulin in the treatment of twelve youths with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Child Adolesc Psychopharmacol 25:65-9
Latimer, M Elizabeth; L'Etoile, Nathan; Seidlitz, Jakob et al. (2015) Therapeutic plasma apheresis as a treatment for 35 severely ill children and adolescents with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Child Adolesc Psychopharmacol 25:70-5
Toufexis, Megan D; Hommer, Rebecca; Gerardi, Diana M et al. (2015) Disordered eating and food restrictions in children with PANDAS/PANS. J Child Adolesc Psychopharmacol 25:48-56

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