During the past year, we have continued to analyze the data from this prospective cohort study that covers a total observation period of 30 years for this cohort of young adults who have been followed since the age of 18. We examined the specific patterns of comorbidity by headache subtype, and their respective impact on the affected individual over time. Results show that there was substantial comorbidity with mood and anxiety disorders across headache subtypes. Only social phobia and hypomania were specifically associated with migraine, and prospective analysis shows that the onset of migraine generally precedes that of these disorders. As compared to migraine only, migraine comorbidity with anxiety or mood disorders was associated with greater levels of consulting a physician, treatment seeking, medication use, years symptomatic, distress and impairment. Analyses led by our colleagues in Zurich assessed sex differences in schizophrenia (Rossler et al, 2012). They applied two different measures of sub-clinical psychosis representing schizotypal signs and schizophrenia nuclear symptoms. Using cross-sectional and longitudinal analyses, they found no significant sex differences in sub-clinical psychosis over time with respect to age of onset, symptomatology, course, or psycho-social outcome. Thus it appears that sex differences in psychosis manifest themselves at the high end of the continuum (full-blown schizophrenia) rather than within the sub-threshold range. Possibly males and females have separate thresholds for certain symptoms because they are differently vulnerable or exposed to various risk factors. The gender difference in lifetime somatic depression was compared to that of pure depression using this unique data (Silverstein et al, 2012). Public Health Impact: This study provides valuable insight on the association between specific headache subtypes and psychiatric conditions, as well as the differential impact of these subtypes on the affected individual using prospective data from a population-based sample. Understanding the specificity of these associations will aid in our efforts to more accurately detect at-risk individuals, inform the development of more targeted prevention and treatment efforts and help refine studies examining the etiology of these conditions. Future Plans: During the next year, we plan to analyze the 30 year follow up data on the following topics: 1) longitudinal course of nonrestorative sleep and its correlation with nighttime insomnia symptoms;2) short sleep duration, late bedtime, and sleep disturbances as predictors of poor mental health: mental disorder, chronic unexplained pain, suicidality, smoking, and alcoholism;3) the SCL-90 depression course over time;4) depression subtypes and persistent fatigue/neurasthenia.

Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2012
Total Cost
$85,887
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
Zip Code
Angst, J; Paksarian, D; Cui, L et al. (2015) The epidemiology of common mental disorders from age 20 to 50: results from the prospective Zurich cohort Study. Epidemiol Psychiatr Sci :1-9
Rossler, Wulf; Angst, Jules; Gamma, Alex et al. (2011) Reappraisal of the interplay between psychosis and depression symptoms in the pathogenesis of psychotic syndromes: results from a twenty-year prospective community study. Eur Arch Psychiatry Clin Neurosci 261:11-9
Landolt, Karin; Ajdacic-Gross, Vladeta; Angst, Jules et al. (2010) Smoking and psychiatric disorders: have subthreshold disorders been overlooked? Nicotine Tob Res 12:516-20
Ajdacic-Gross, Vladeta; Landolt, Karin; Angst, Jules et al. (2009) Adult versus adolescent onset of smoking: how are mood disorders and other risk factors involved? Addiction 104:1411-9