The NIMH Psychiatric Consultation Liaison Service (PCLS) provides important psychiatric services to the many constituencies of the NIH. While providing such services to the NIH Community, PCLS clinicians conduct research and collaborate with NIH investigators by providing expertise in the areas of psychiatric, neurocognitive, and psychosocial functioning in NIH research subjects who often have complex medical and neuropsychiatric symptoms. Patient-subjects enrolled in research trials in other Institutes/Centers at the NIH offer unparalleled opportunities to explore the roles of specific genes (e.g., monogenic diseases such as methylmalonic acidemia (MMA)) and specific therapies (e.g., interferon in hepatitis) in psychiatry and neurodevelopment. Psychosomatic medicine trainees on the PCLS are encouraged during their rotations to pursue research projects that result in publications in peer reviewed journals, including literature reviews, case reports and poster presentations at national conferences. Active NIH research collaborators include the CC Bioethics Department, NCI Pediatric Oncology Branch (POB), the NIAID HIV/AIDS Service, and the Smith-Magenis Research Team to name just a few. The PCLS Neuropsychology Consultation Service performs neuropsychological evaluations for neurocognitive phenotyping of medical disorders resulting in research collaborations with other Institutes such as NIAMS, NHGRI, NIAID, NHLBI, NINDS and others. The PCLS conducts collaborative research with the NCI POB and provides research support to the Pediatric Oncology Psychosocial Research Program which studies palliative care, psychopharmacologic management in pediatric oncology patients, sibling, parent and caregivers concerns, and screening for distress in bone marrow transplantation recipients as compared to other chronic diseases, among other topics. This active research program on psychiatric and psychosocial aspects of pediatric oncology care has led to several shared protocols including evaluation of a distress thermometer in pediatric medically ill populations, characterization of "lone" parenting and a protocol to understand the experiences and needs of international families whose children are in research all of which resulted in recent publications. The PCLS research group provides mental health consultation on a number of educational brochures and booklets and recently developed "Voicing My Choices," an advance care planning guide for adolescents and young adults. Over 9000 copies of "Voicing My Choices" has been distributed nationally and internationally. It has been translated into Spanish and Italian. The PCLS group is also studying assessment instruments of mood and anxiety disorders for adolescents and young adult (AYA) healthy volunteers and AYA with cancer. The PCLS research team has taken a central role in NIMH's collaboration with NIAID and the District of Columbia (DC) in establishing an interdisciplinary, cross-institutional research collaborative effort with local investigators (see list of extramural collaborators), the DC-NIH Partnership for AIDS Progress (DC PFAP), to enhance knowledge of the biopsychosocial mental health aspects of HIV/AIDS. PCLS staff are working with DC Government leaders, clinical providers and administration, and community groups to identify gaps in services and knowledge to develop related research opportunities. PCLS researchers have co-founded and co-chaired the DC CFAR "Mental Health and Neuroscience" Scientific Interest Group which includes more than 30 investigators from DC based universities and meets monthly to discuss research collaborations. PCLS researchers have also co-founded and co-chaired the intramural NeuroHIV Interest Group Steering Committee, which meets monthly and oversees and coordinates five intramural research protocols at various stages of development;two protocols were co-authored and are co-led by PCLS researchers while all five receive substantial logistical support from PCLS, including neuropsychological testing and mental health screening which are among the key outcome measures for all these protocols. The PCLS research group continues to describe the processes involved in developing adequate programs for the protection of healthy volunteers as well as vulnerable subjects while conducting cutting-edge research. An informed consent training video produced by the Clinical Research Advocates (CRAs) of the Human Subjects Protections Unit (HSPU), in the Office of the Clinical Director, is now being used for training in all the Graduate Medical Education programs at the NIH as well as throughout the CC. The CRAs continue to provide training courses as well as present at national meetings on their experiences regarding implementing processes to standardize the evaluation and protection of vulnerable subjects in research. They continue to serve on the Ability to Consent Assessment Team (ACAT) with the CC Bioethics department and are utilized frequently throughout the Clinical Center to provide additional safeguards to vulnerable subjects. The PCLS also provides mental health consultation to the National Institute for Child Human Development (NICHD), and assigns a mental health professional to serve on the NICHD IRB. PCLS faculty regularly serve as reviewers for peer reviewed journals in mental health, psychosomatic medicine, pediatrics, neuropsychology, ethics, and public health. The PCLS research group is involved in several timely research projects that align with NIMH's mission to improve suicide prevention strategies. Three suicide screening projects address suicide screening in the medical setting. This past year we concluded a multisite study of pediatric EDs at Children's National Medical Center, Boston Children's Hospital and Nationwide Children's Hospital in Columbus, Ohio led by the PCLS group. A four-item screening instrument was developed, the ASQ (Ask Suicide-Screening Questions), and has been published by Archives of Pediatrics and Adolescent Medicine (now JAMA Pediatrics). To address the issue of suicidality in hospital settings, the PCLS research group created a suicide screening instrument and educational program to assist nurses on inpatient medical units with suicide assessment. The Ask Suicide-Screening Questions to Everyone in Medical Settings (asQem) Quality Improvement Project was initiated in January 2012 and was published in Psychosomatics in 2013. The third project involves an international collaboration and is focused on developing a suicide screening tool for youth with developmental delay and adults with intellectual disabilities. Phase 2 of this study was completed in July 2013 with the first manuscript in preparation. Due to the PCLS's expertise in this area of research, PCLS members have presented in-services to physicians, nurses and NIH police around the NIH CC on the topic of suicide prevention. The PCLS research team had a productive year with more than a dozen posters, more than 20 papers and numerous presentations and educational courses in the past year.

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Kapetanovic, Suad; Dass-Brailsford, Priscilla; Nora, Diana et al. (2014) Mental health of HIV-seropositive women during pregnancy and postpartum period: a comprehensive literature review. AIDS Behav 18:1152-73
Horowitz, Lisa M; Bridge, Jeffrey A; Pao, Maryland et al. (2014) Screening youth for suicide risk in medical settings: time to ask questions. Am J Prev Med 47:S170-5
Zadeh, Sima; Pao, Maryland; Wiener, Lori (2014) Opening end-of-life discussions: How to introduce Voicing My CHOiCESýýý, an advance care planning guide for adolescents and young adults. Palliat Support Care :1-9
J Pavletic, Adriana; Pao, Maryland (2014) Popular dietary supplement causes false-positive drug screen for amphetamines. Psychosomatics 55:206-7
Kapetanovic, Suad; Griner, Ray; Zeldow, Bret et al. (2014) Biomarkers and neurodevelopment in perinatally HIV-infected or exposed youth: a structural equation model analysis. AIDS 28:355-64
Malee, Kathleen M; Mellins, Claude A; Huo, Yanling et al. (2014) Prevalence, incidence, and persistence of psychiatric and substance use disorders among mothers living with HIV. J Acquir Immune Defic Syndr 65:526-34
Mavrides, Nicole; Pao, Maryland (2014) Updates in paediatric psycho-oncology. Int Rev Psychiatry 26:63-73
Pavletic, A J; Pao, M; Pine, D S et al. (2014) Screening electrocardiograms in psychiatric research: implications for physicians and healthy volunteers. Int J Clin Pract 68:117-21
Horowitz, Lisa M; Snyder, Deborah; Ludi, Erica et al. (2013) Ask suicide-screening questions to everyone in medical settings: the asQ'em Quality Improvement Project. Psychosomatics 54:239-47
Pao, Maryland; Wiener, Lori; Zadeh, Sima (2013) Talking with patients about dying. N Engl J Med 368:480

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