During the current fiscal year we have made significant improvements in a mattress in development that monitors apnea in infants and turns on low-level noise-like vibrations in the mattress that produce a switch from apnea to eupnea without waking the infant. Preliminary results in the Parkinson's project have shown that low level electrical noise is sufficient to cause transitions between the non-tremor and the tremor state in patients in the surgical suite immediately after a Deep Brain Stimulation (DBS) electrode has been implanted. Suppression of the tremor was produced using rectangular current pulses administered by a traditional DBS device. Additional experiments will, hopefully, demonstrate noise-induced transitions from the tremor to the non-tremor state without need of the traditional DBS device.
|Clay, John R (2013) A comparative analysis of models of Na(+) channel gating for mammalian and invertebrate nonmyelinated axons: Relationship to energy efficient action potentials. Prog Biophys Mol Biol 111:1-7|
|Clay, John R; Paydarfar, David; Forger, Daniel B (2008) A simple modification of the Hodgkin and Huxley equations explains type 3 excitability in squid giant axons. J R Soc Interface 5:1421-8|