During the current fiscal year we have made significant improvements in a mattress in development that monitors apnea in infants and turns on low-level noise-like vibrations in the mattress that produce a switch from apnea to eupnea without waking the infant. Preliminary results in the Parkinson's project have shown that low level electrical noise is sufficient to cause transitions between the non-tremor and the tremor state in patients in the surgical suite immediately after a Deep Brain Stimulation (DBS) electrode has been implanted. Suppression of the tremor was produced using rectangular current pulses administered by a traditional DBS device. Additional experiments will, hopefully, demonstrate noise-induced transitions from the tremor to the non-tremor state without need of the traditional DBS device.
|Clay, John R (2013) A comparative analysis of models of Na(+) channel gating for mammalian and invertebrate nonmyelinated axons: Relationship to energy efficient action potentials. Prog Biophys Mol Biol 111:1-7|
|Clay, John R (2013) A novel analysis of excitatory currents during an action potential from suprachiasmatic nucleus neurons. J Neurophysiol 110:2574-9|
|Clay, John R; Forger, Daniel B; Paydarfar, David (2012) Ionic mechanism underlying optimal stimuli for neuronal excitation: role of Na+ channel inactivation. PLoS One 7:e45983|
|Forger, Daniel B; Paydarfar, David; Clay, John R (2011) Optimal stimulus shapes for neuronal excitation. PLoS Comput Biol 7:e1002089|
|Clay, John R; Paydarfar, David; Forger, Daniel B (2008) A simple modification of the Hodgkin and Huxley equations explains type 3 excitability in squid giant axons. J R Soc Interface 5:1421-8|