A number of efforts in the laboratory are devoted to understanding the physiology of volition. This includes the sense of willing to make a movement and the sense of agency, the sense of personal responsibility for the movement that has occurred. We have been trying to devise improved techniques to get quantitative measures of the timing of these subjective events. To determine which areas of the brain are activated with the sense of agency when making voluntary movement, we have developed an MRI-compatible dataglove which subjects wore while making hand movements in the scanner. Subjects viewed their movements in real-time and the visual feedback they received was varied during the experiment to simulate different degrees of voluntary control. We have determined some EEG and MEG methods to predict in real time when someone is going to move and what movement they will make. We have optimized features and classification methods for the prediction. We have completed studies identifying that persons are not necessarily thinking about movement when a movement prediction can be made. The learning of motor skills is an important function. We have been studying how movements become automatic, that is, the stage of learning where much attention does not need to be devoted to an action. We are carrying out studies on the learning of rhythms, and on the influence of reward on learning. Another feature of automaticity, that has not been studied, is how movements deteriorate at the automatic stage when attention is devoted to them. We will look at these phenomena with fMRI, TMS and EEG. We will use information learned in these studies to investigate patients with focal hand dystonia. The ability to make selective movements, particularly of individual fingers, is a critical human function. Anatomical and physiological features of the motor system make this difficult since most neurons (other than alpha motoneurons in the spinal cord and brainstem) are not muscle specific. Our hypothesis is that selective motor action must require inhibitory mechanisms, and we are seeking to understand them using TMS. We refer to this process as surround inhibition, as muscles not intended for the selective action need to be inhibited. Many inhibitory processes in the cortex, such as short intracortical inhibition and short afferent inhibition, can be analyzed at rest and with movement. Such studies should reveal which mechanisms are responsible for surround inhibition.

Project Start
Project End
Budget Start
Budget End
Support Year
29
Fiscal Year
2013
Total Cost
$1,164,044
Indirect Cost
City
State
Country
Zip Code
Hallett, Mark (2016) Physiology of free will. Ann Neurol 80:5-12
Mitchell, Simon; Gao, Jennifer; Hallett, Mark et al. (2016) The Role of Social Novelty in Risk Seeking and Exploratory Behavior: Implications for Addictions. PLoS One 11:e0158947
Shields, Jessica; Park, Jung E; Srivanitchapoom, Prachaya et al. (2016) Probing the interaction of the ipsilateral posterior parietal cortex with the premotor cortex using a novel transcranial magnetic stimulation technique. Clin Neurophysiol 127:1475-80
Cho, Hyun Joo; Panyakaew, Pattamon; Thirugnanasambandam, Nivethida et al. (2016) Dynamic modulation of corticospinal excitability and short-latency afferent inhibition during onset and maintenance phase of selective finger movement. Clin Neurophysiol 127:2343-9
Ramos, Vesper Fe Marie Llaneza; Esquenazi, Alina; Villegas, Monica Anne Faye et al. (2016) Temporal discrimination threshold with healthy aging. Neurobiol Aging 43:174-9
Srivanitchapoom, Prachaya; Park, Jung E; Thirugnanasambandam, Nivethida et al. (2016) Inducing LTD-Like Effect in the Human Motor Cortex with Low Frequency and Very Short Duration Paired Associative Stimulation: An Exploratory Study. Neural Plast 2016:3920298
Ewen, Joshua B; Pillai, Ajay S; McAuliffe, Danielle et al. (2016) Practicing Novel, Praxis-Like Movements: Physiological Effects of Repetition. Front Hum Neurosci 10:22
Panyakaew, Pattamon; Cho, Hyun Joo; Srivanitchapoom, Prachaya et al. (2016) Cerebellar brain inhibition in the target and surround muscles during voluntary tonic activation. Eur J Neurosci 43:1075-81
Douglas, Zachary H; Maniscalco, Brian; Hallett, Mark et al. (2015) Modulating conscious movement intention by noninvasive brain stimulation and the underlying neural mechanisms. J Neurosci 35:7239-55
Karabanov, Anke Ninija; Paine, Rainer; Chao, Chi Chao et al. (2015) Participation of the classical speech areas in auditory long-term memory. PLoS One 10:e0119472

Showing the most recent 10 out of 60 publications