This project is designed to evaluate the molecular markers in patients that are undergoing radiotherapy in serum and urine. This work is prospective and hypothesis generating. In the past year we have initiated an international trial of patients with glioblastoma multiforme (GBM) to determine if urinary vascular endothelial growth factor (VEGF) or matrix metalloproteinase-2 (MMP-2) can help predict outcome. This past year we have worked on standardizing the collection procedures, analysis procedures, and the many biomolecules that could incorrectly alter the VEGF levels and we have published 2 manuscripts on specimen preparation and storage.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
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National Cancer Institute Division of Clinical Sciences
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Steeg, Patricia S; Camphausen, Kevin A; Smith, Quentin R (2011) Brain metastases as preventive and therapeutic targets. Nat Rev Cancer 11:352-63
de Groot, John F; Piao, Yuji; Tran, Hai et al. (2011) Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept. Clin Cancer Res 17:4872-81
Stall, Bronwyn; Zach, Leor; Ning, Holly et al. (2010) Comparison of T2 and FLAIR imaging for target delineation in high grade gliomas. Radiat Oncol 5:5
Shabason, Jacob E; Camphausen, Kevin (2010) Cancer stem cells as a prognostic indicator for glioblastoma multiforme. Biomark Med 4:127-8
Shabason, Jacob E; Tofilon, Philip J; Camphausen, Kevin (2010) HDAC inhibitors in cancer care. Oncology (Williston Park) 24:180-5
Russo, Andrea L; Jedlicka, Kimberly; Wernick, Meredith et al. (2009) Urine analysis and protein networking identify met as a marker of metastatic prostate cancer. Clin Cancer Res 15:4292-8
Brown, Aaron P; Wendler, David S; Camphausen, Kevin A et al. (2008) Performing nondiagnostic research biopsies in irradiated tissue: a review of scientific, clinical, and ethical considerations. J Clin Oncol 26:3987-94
Hayward, Robert M; Kirk, Melissa J; Sproull, Mary et al. (2008) Post-collection, pre-measurement variables affecting VEGF levels in urine biospecimens. J Cell Mol Med 12:343-50
Baschnagel, Andrew; Wolters, Pamela L; Camphausen, Kevin (2008) Neuropsychological testing and biomarkers in the management of brain metastases. Radiat Oncol 3:26
Brown, Aaron P; Citrin, Deborah E; Camphausen, Kevin A (2008) Clinical biomarkers of angiogenesis inhibition. Cancer Metastasis Rev 27:415-34