The goal of this project is to study the interaction of radiotherapy and molecularly targeted agents. This project focuses on expanding drugs that show synergy in vitro to the in vivo setting, with the goal of translation to the clinic. This is a translational project. We begin in the laboratory testing drugs in combination with radiotherapy in vitro. Once in vitro sensitivity is comfirmed then we do in vivo work with sc or ic animal models. If a drug is shown to sensitize tumor cells to radiation then we bring it to the clinic.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
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National Cancer Institute Division of Clinical Sciences
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Sproull, Mary; Kramp, Tamalee; Tandle, Anita et al. (2017) Multivariate Analysis of Radiation Responsive Proteins to Predict Radiation Exposure in Total-Body Irradiation and Partial-Body Irradiation Models. Radiat Res 187:251-258
Tandle, Anita; Camphausen, Kevin (2016) Mitotic Protein Kinase 1: Role in Spindle Assembly Checkpoint Revisited. J Cancer Clin Trials 1:
Gordon, Ira K; Lu, Jie; Graves, Christian A et al. (2015) Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma. Mol Cancer Ther 14:1540-1547
Krauze, Andra V; Myrehaug, Sten D; Chang, Michael G et al. (2015) A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma. Int J Radiat Oncol Biol Phys 92:986-992
Maachani, Uday Bhanu; Kramp, Tamalee; Hanson, Ryan et al. (2015) Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins. Mol Cancer Res 13:852-62
Maachani, Uday B; Tandle, Anita; Shankavaram, Uma et al. (2015) Modulation of miR-21 signaling by MPS1 in human glioblastoma. Oncotarget :
Tandle, Anita T; Kramp, Tamalee; Kil, Whoon J et al. (2013) Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation. Eur J Cancer 49:3020-8
Kil, Whoon Jong; Tofilon, Philip J; Camphausen, Kevin (2012) Post-radiation increase in VEGF enhances glioma cell motility in vitro. Radiat Oncol 7:25
Shankavaram, Uma T; Bredel, Markus; Burgan, William E et al. (2012) Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma. J Cell Mol Med 16:545-54
Jamal, Muhammad; Rath, Barbara H; Tsang, Patricia S et al. (2012) The brain microenvironment preferentially enhances the radioresistance of CD133(+) glioblastoma stem-like cells. Neoplasia 14:150-8

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