Abstract

The goal of this project is to study the interaction of radiotherapy and molecularly targeted agents. This project focuses on expanding drugs that show synergy in vitro to the in vivo setting, with the goal of translation to the clinic. This is a translational project. We begin in the laboratory testing drugs in combination with radiotherapy in vitro. Once in vitro sensitivity is comfirmed then we do in vivo work with sc or ic animal models. If a drug is shown to sensitize tumor cells to radiation then we bring it to the clinic.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIASC010373-12
Application #
8554050
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2012
Total Cost
$1,153,514
Indirect Cost

  Institution

Name
National Cancer Institute Division of Clinical Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Ho, Winson S; Sizdahkhani, Saman; Hao, Shuyu et al. (2018) LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation. Cancer Lett 415:217-226
Wahba, Amy; Rath, Barbara H; O'Neill, John W et al. (2018) The XPO1 Inhibitor Selinexor Inhibits Translation and Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and In Vivo. Mol Cancer Ther 17:1717-1726
Timme, Cindy R; Rath, Barbara H; O'Neill, John W et al. (2018) The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and as Orthotopic Xenografts. Mol Cancer Ther 17:1207-1216
Hao, Shuyu; Song, Hua; Zhang, Wei et al. (2018) Protein phosphatase 2A inhibition enhances radiation sensitivity and reduces tumor growth in chordoma. Neuro Oncol 20:799-809
Sproull, Mary; Kramp, Tamalee; Tandle, Anita et al. (2017) Multivariate Analysis of Radiation Responsive Proteins to Predict Radiation Exposure in Total-Body Irradiation and Partial-Body Irradiation Models. Radiat Res 187:251-258
Tandle, Anita; Camphausen, Kevin (2016) Mitotic Protein Kinase 1: Role in Spindle Assembly Checkpoint Revisited. J Cancer Clin Trials 1:
Maachani, Uday B; Tandle, Anita; Shankavaram, Uma et al. (2015) Modulation of miR-21 signaling by MPS1 in human glioblastoma. Oncotarget :
Krauze, Andra V; Myrehaug, Sten D; Chang, Michael G et al. (2015) A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma. Int J Radiat Oncol Biol Phys 92:986-992
Maachani, Uday Bhanu; Kramp, Tamalee; Hanson, Ryan et al. (2015) Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins. Mol Cancer Res 13:852-62
Gordon, Ira K; Lu, Jie; Graves, Christian A et al. (2015) Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma. Mol Cancer Ther 14:1540-1547

Showing the most recent 10 out of 45 publications