The goal of this effort is to use various bioinformatics approaches to analyze data regarding complex human disease, aging, and the role of disease processes in aging. Over the years we have applied this effort to a number of related projects including The Genetic Association Database, development of disease related Gene Sets for multiplex analysis of high-throughput data, among others. This includes summaries of genetic associations for Type 2 Diabetes, Alzheimer's disease, Obesity, Autoimmune diseases, among many others. We are currently using a bioinformatic approach to analyze population based aging related studies based on methylation and large scale gene expression studying increasing genomic instability with age.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICAG000613-09
Application #
9348265
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Becker, Kevin G (2018) Autism and Socioeconomic Status-An Immune Link? Am J Public Health 108:e16
Tsuchiya, Motohiro; Kalurupalle, Swathi; Kumar, Parameet et al. (2016) RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF. RNA Biol 13:837-47
Noren Hooten, Nicole; Martin-Montalvo, Alejandro; Dluzen, Douglas F et al. (2016) Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence. Aging Cell 15:572-81
Panda, Amaresh C; Abdelmohsen, Kotb; Martindale, Jennifer L et al. (2016) Novel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis. Nucleic Acids Res 44:2393-408
Zhang, Peisu; Abdelmohsen, Kotb; Liu, Yong et al. (2015) Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity. Nat Commun 6:8888
De, Supriyo; Zhang, Yongqing; Wolkow, Catherine A et al. (2013) Genome-wide modeling of complex phenotypes in Caenorhabditis elegans and Drosophila melanogaster. BMC Genomics 14:580
Arighi, Cecilia N; Carterette, Ben; Cohen, K Bretonnel et al. (2013) An overview of the BioCreative 2012 Workshop Track III: interactive text mining task. Database (Oxford) 2013:bas056
Becker, Kevin G (2012) Male gender bias in autism and pediatric autoimmunity. Autism Res 5:77-83
Becker, Kevin G (2011) Autism, immune dysfunction and Vitamin D. Acta Psychiatr Scand 124:74; author reply 74-5
Becker, Kevin G; Holmes, Karen A; Zhang, Yongqing (2011) Aging-kb: a knowledge base for the study of the aging process. Mech Ageing Dev 132:592-4

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