The following projects have been supported by Mouse Metabolism Core Laboratory in FY 2014 1. DK031131 Role of muscarinic acetylcholine receptors in glucose and energy homeostasis Principal Investigator: Jurgen Wess (LBC, NIDDK) 2. DK043313 Role of the Gnas Gene in Metabolic Regulation Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 3. DK043315 Role of Gs-alpha in central regulation of energy and glucose metabolism Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 4. DK043316 Role of Gs-alpha in regulation of adipose tissue growth and function Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 5. DK025102 Erythropoietin receptor and glucose metabolism Principal Investigator: Constance T Noguchi (MCB, NIDDK) 6. DK075004 Identification of novel molecules and pathways that modulate adipogenesis Principal Investigator: Elisabetta Mueller (GDDB, NIDDK) 7. DK075003 Regulation of PPARgamma expression and adipogenesis by PTIP-associated factors Principal Investigator: Kai Ge (NRB, NIDDK) 8. DK075017 Epigenetic regulation of adipogenesis. Principal Investigator: Kai Ge (NRB, NIDDK) 9. DK031116 Development of P2Y receptor ligands Principal Investigator: Kenneth A Jacobson (MR, NIDDK) 10. DK060101 Targeted disruption the enzymes of O-GlcNAc cycling: animal models of disease Principal Investigator: John A Hanover (LCMB, NIDDK) 11. DK075057 DEOB Physiology and Pharmacology of BRS-3 (Bombesin Receptor Subtype-3) Principal Investigator: Marc L. Reitman (DEOB, NIDDK) 12. DK075063 DEOB What can body temperature tell us about energy homeostasis? Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 13. DK075064 DEOB Role of brown adipose tissue (BAT) in energy balance Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 14. DK061000 LGP Genetic Approaches to Understanding Organ Development and Function Principal Investigator: Lothar Hennighausen (LGP, NIDDK) 15. DK056018-06 (2012) Sphingolipid Biology and Regulation of Metabolism Principal Investigator: Richard L Proia (GDDB, NIDDK) 16. DK056014 Mouse Models of Novel Sphingolipid Biology and Disease Principal Investigator: Richard L Proia (GDDB, NIDDK) 17. DK036150 Organization and regulation of the human insulin locus Principal Investigator: Gary Felsenfeld (LMB, NIDDK) 18. DK075035 Genes associated with endocrine tumorigenesis Principal Investigator: Sunita K Agarwal (MDB, NIDDK) 19. DK055106 Transforming growth factor - beta superfamily signaling in diabetes and obesity Principal Investigator: Sushil Rane (DB, NIDDK) 20. DK055107 Cell cycle regulators in diabetes and obesity Principal Investigator: Sushil Rane (DB, NIDDK) 21. BC005708 Xenobiotic receptors Principal Investigator: Frank J Gonzalez (LM, NCI) 22. HD000641 Physiology, psychology, and genetics of obesity Principal Investigator: Jack Adam Yanovski (UGO, NICHD) 23. HD000642 Molecular Genetics of Adrenocortical Tumors And Related Disorders Principal Investigator: Constantine A Stratakis (PDEG, NICHD)

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10
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2014
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U.S. National Inst Diabetes/Digst/Kidney
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Xiao, Cuiying; Piñol, Ramón A; Carlin, Jesse Lea et al. (2018) Corrigendum to ""Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism"" [Mol Metabol 6 (2017) 1540-1550]. Mol Metab 9:220
Jain, Shalini; Panyutin, Anna; Liu, Naili et al. (2018) Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab 315:E357-E366
Xu, Lingyan; Ma, Xinran; Verma, Narendra Kumar et al. (2018) Ablation of PPAR? in subcutaneous fat exacerbates age-associated obesity and metabolic decline. Aging Cell 17:
Podyma, Brandon; Sun, Hui; Wilson, Eric A et al. (2018) The stimulatory G protein Gs? is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism. J Biol Chem 293:10993-11005
Liu, Wenli; Aerbajinai, Wulin; Li, Hongzhen et al. (2018) Olfactomedin 4 Deletion Improves Male Mouse Glucose Intolerance and Insulin Resistance Induced by a High-Fat Diet. Endocrinology 159:3235-3244
Zhuang, Lenan; Jang, Younghoon; Park, Young-Kwon et al. (2018) Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun 9:1796
Carlin, Jesse Lea; Jain, Shalini; Duroux, Romain et al. (2018) Activation of adenosine A2A or A2B receptors causes hypothermia in mice. Neuropharmacology 139:268-278
Kim, So Yoon; Lee, Ji-Hyeon; Merrins, Matthew J et al. (2017) Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary ?-Cell Dysfunction to Progressive Depletion of ?-Cell Mass and Diabetes. J Biol Chem 292:3841-3853
Carlin, Jesse Lea; Jain, Shalini; Gizewski, Elizabeth et al. (2017) Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms. Neuropharmacology 114:101-113
Shin, Hyunsu; Ma, Yinyan; Chanturiya, Tatyana et al. (2017) Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice. Cell Metab 26:764-777.e5

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