Metabolic Studies of Mouse Models of Obesity and Diabetes

Gavrilova, Oksana

Abstract

The following projects have been supported by Mouse Metabolism Core in FY 2018: 1. DK031131 Role of muscarinic acetylcholine receptors in glucose and energy homeostasis Principal Investigator: Jurgen Wess (LBC, NIDDK) 2. DK043313 Role of the Gnas Gene in Metabolic Regulation Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 3. DK043315 Role of Gs-alpha in central regulation of energy and glucose metabolism Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 4. DK043316 Role of Gs-alpha in regulation of adipose tissue growth and function Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 5. DK025102 Erythropoietin receptor and glucose metabolism Principal Investigator: Constance T Noguchi (MCB, NIDDK) 6. DK031117 Development of drugs acting at adenosine receptors Principal Investigator: Kenneth A Jacobson (MR, NIDDK) 7. DK075057 DEOB Physiology and pharmacology of BRS-3 (Bombesin Receptor Subtype-3) Principal Investigator: Marc L. Reitman (DEOB, NIDDK) 8. DK075063 What can body temperature tell us about energy homeostasis? Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 9. DK075064 Role of brown adipose tissue (BAT) in energy balance Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 10. DK055106 Transforming growth factor - beta superfamily signaling in diabetes and obesity Principal Investigator: Sushil Rane (DEOB, NIDDK) 11. DK055107 Cell cycle regulators in diabetes and obesity Principal Investigator: Sushil Rane (DEOB, NIDDK) 12. DK075017 Epigenetic Regulation of Adipogenesis Principal Investigator: Kai Ge (LERB, NIDDK) 13. DK075013 Nonalcoholic steatohepatitis: natural History, pathogenesis and therapy Principal Investigator: Yaron Rotman (LDB, NIDDK) 14. DK054510 Identification of human genes of iron homeostasis Principal Investigator: Caroline C Philpott (LDB, NIDDK) 15. DK075033 Epigenetic and Developmental Regulation of Mammalian Genes Principal Investigator: Ann Dean (LCDB, NIDDK) 16. DK053218 Vitamin C (ascorbic acid) physiology Principal Investigator: Mark A Levine (DDB, NIDDK) 17. HL006004-07 Olfactomedin 4 is a key regulator of colon cancer progression Principal Investigator: Griffin P Rodgers (MCHB, NHLBI) 18. DK075087 Probing neural circuits underlying satiety Principal Investigator: Michael J Krashes (DEOB, NIDDK) 19. BC005708 Xenobiotic receptors Principal Investigator: Frank J Gonzalez (LM, NCI) 20. BC010390 Role of Neurotrophins in the Development of the Mammalian Nervous System Principal Investigator: Lino Tessarollo (MCGP, NCI) 21. BC011168 Physiological and pathological functions of E3 ubiquitin ligase SMURF. Principal Investigator: Ying Zhang (LCMB, NCI) 22. HD000642 Molecular Genetics of Adrenocortical Tumors and Related Disorders Principal Investigator: Constantine A Stratakis (PDEG, NICHD)

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Scientific Cores Intramural Research (ZIC)
• Project #: 1ZICDK070002-14
• Application #: 9775044
• Support Year: 14
• Fiscal Year: 2018

Institution

• Name: U.S. National Inst Diabetes/Digst/Kidney

Publications

Xiao, Cuiying; Piñol, Ramón A; Carlin, Jesse Lea et al. (2018) Corrigendum to ""Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism"" [Mol Metabol 6 (2017) 1540-1550]. Mol Metab 9:220

Jain, Shalini; Panyutin, Anna; Liu, Naili et al. (2018) Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab 315:E357-E366

Xu, Lingyan; Ma, Xinran; Verma, Narendra Kumar et al. (2018) Ablation of PPAR? in subcutaneous fat exacerbates age-associated obesity and metabolic decline. Aging Cell 17:

Podyma, Brandon; Sun, Hui; Wilson, Eric A et al. (2018) The stimulatory G protein Gs? is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism. J Biol Chem 293:10993-11005

Liu, Wenli; Aerbajinai, Wulin; Li, Hongzhen et al. (2018) Olfactomedin 4 Deletion Improves Male Mouse Glucose Intolerance and Insulin Resistance Induced by a High-Fat Diet. Endocrinology 159:3235-3244

Zhuang, Lenan; Jang, Younghoon; Park, Young-Kwon et al. (2018) Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun 9:1796

Carlin, Jesse Lea; Jain, Shalini; Duroux, Romain et al. (2018) Activation of adenosine A2A or A2B receptors causes hypothermia in mice. Neuropharmacology 139:268-278

Chen, Min; Shrestha, Yogendra B; Podyma, Brandon et al. (2017) Gs? deficiency in the dorsomedial hypothalamus underlies obesity associated with Gs? mutations. J Clin Invest 127:500-510

Alexaki, Aikaterini; Clarke, Benjamin A; Gavrilova, Oksana et al. (2017) De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. J Biol Chem 292:3929-3939

Park, Sung-Jun; Gavrilova, Oksana; Brown, Alexandra L et al. (2017) DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab 25:1135-1146.e7