Data for 20 patients and 19 normal volunteers showed that the relationship between the PAT index and IR signal, calculated as a ratio between temperature before and during the first 100 sec of occlusion, holds promise to simplify and substantially shorten the procedure of endothelial assessment. Thus, peripheral vascular endothelial function testing with both PAT and IR methods correlates with the presence or absence of Sickle Cell Disease. These data suggest that peripheral vascular endothelial function testing with IR imaging is feasible, and this is an important next step in development of this non-invasive technology capable of identifying, differentiating, and locating peripheral vascular beds with endothelial dysfunction.

Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2010
Total Cost
$81,292
Indirect Cost
Name
National Institute of Biomedical Imaging and Bioengineering
Department
Type
DUNS #
City
State
Country
Zip Code
Webb, R Chad; Ma, Yinji; Krishnan, Siddharth et al. (2015) Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow. Sci Adv 1:e1500701
Chang, Ken; Yoon, Stephen; Sheth, Niral et al. (2015) Rapid vs. delayed infrared responses after ischemia reveal recruitment of different vascular beds. Quant Infrared Thermogr J 12:173-183
Balageas, Daniel L; Roche, Jean-Michel; Leroy, François-Henri et al. (2015) THE THERMOGRAPHIC SIGNAL RECONSTRUCTION METHOD: A POWERFUL TOOL FOR THE ENHANCEMENT OF TRANSIENT THERMOGRAPHIC IMAGES. Biocybern Biomed Eng 35:1-9