The NIEHS knock out core (KOC) is a servicing core facility with some research opportunity. Each project in the core is a long-term commitment from start to finish, and several projects are at different stages of completion in the core at any given time of the year. The core works very closely with the investigator since the inception of the project, which typically starts with meeting the PI's group for developing the targeting strategy and continues until the mutant mouse is made. KOC helps investigators to generate the mutant mouse customized to their research needs;including traditional knockouts, conditional knockout and knock-ins. It also provides assistance to establish and culturing the mutant cells for in vitro studies, along with dissecting the early stage embryos and help establishing the genotyping strategies.

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Cheng, Jennifer; Dackor, Ryan T; Bradbury, J Alyce et al. (2016) Contribution of alveolar type II cell-derived cyclooxygenase-2 to basal airway function, lung inflammation, and lung fibrosis. FASEB J 30:160-73
Sciolino, Natale R; Plummer, Nicholas W; Chen, Yu-Wei et al. (2016) Recombinase-Dependent Mouse Lines for Chemogenetic Activation of Genetically Defined Cell Types. Cell Rep 15:2563-73
Zhang, Yanshuai; McNerny, Erin Gatenby; Terajima, Masahiko et al. (2016) Loss of BMP signaling through BMPR1A in osteoblasts leads to greater collagen cross-link maturation and material-level mechanical properties in mouse femoral trabecular compartments. Bone 88:74-84
Plummer, Nicholas W; de Marchena, Jacqueline; Jensen, Patricia (2016) A knock-in allele of En1 expressing dre recombinase. Genesis 54:447-54
Robertson, Sabrina D; Plummer, Nicholas W; Jensen, Patricia (2016) Uncovering diversity in the development of central noradrenergic neurons and their efferents. Brain Res 1641:234-44
Badri, Mohammed K; Zhang, Honghao; Ohyama, Yoshio et al. (2016) Ellis Van Creveld2 is Required for Postnatal Craniofacial Bone Development. Anat Rec (Hoboken) 299:1110-20
House, John S; Li, Huiling; DeGraff, Laura M et al. (2015) Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. FASEB J 29:323-35
Li, Rui; Xu, Xizhen; Chen, Chen et al. (2015) CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPARγ. Am J Physiol Endocrinol Metab 308:E270-82
Dai, Meiyan; Wu, Lujin; He, Zuowen et al. (2015) Epoxyeicosatrienoic acids regulate macrophage polarization and prevent LPS-induced cardiac dysfunction. J Cell Physiol 230:2108-19
Plummer, Nicholas W; Evsyukova, Irina Y; Robertson, Sabrina D et al. (2015) Expanding the power of recombinase-based labeling to uncover cellular diversity. Development 142:4385-93

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