The Histology Core of the NEI devotes to supporting the histopathological activities of NEI and other collaborative institutes at the NIH. This consists of accessioning human tissues removed at surgery and autopsy, processing the tissues, preparing and staining slides for microscopy and transmission electron microscopy. Within the NEI, the Histology lab serves the Clinical Branch and all NEI Laboratories and Units under the NEI intramural research program, as well as other NIH institutes, which perform research involving ocular tissues. During FY09, approximately 3266 tissue blocks were prepared from over 6232 specimens and over 6497 slides were cut and stained. Additionally, the laboratory processed case materials sent for ultrastracture, which produced 455 electron microscopic images from 69 thick sections and 60 samples. This fiscal year, 488 consult slides over 96 clinical cases were received. Although about 90% of effort is devoted to NEI duties, the Histology Core also performs service of processing eyes and ocular tissues for research projects inside NIH and outside NIH by collaborations and arrangements. This activity is coordinated with the tissue research request function of the NIH Operations.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICEY000461-02
Application #
7970112
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2009
Total Cost
$363,080
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Dong, Fei; Jin, Xueting; Boettler, Michelle A et al. (2018) A Mouse Model of Schnyder Corneal Dystrophy with the N100S Point Mutation. Sci Rep 8:10219
Wang, Herui; Shepard, Matthew J; Zhang, Chao et al. (2018) Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina. Cancer Res 78:1266-1274
Campos, Maria Mercedes; Abu-Asab, Mones S (2017) Loss of endothelial planar cell polarity and cellular clearance mechanisms in age-related macular degeneration. Ultrastruct Pathol 41:312-319
Chwiki, Sarah; Campos, Maria Mercedes; McLaughlin, Mary E et al. (2017) Adverse effects of antiretroviral therapy on liver hepatocytes and endothelium in HIV patients: An ultrastructural perspective. Ultrastruct Pathol 41:186-195
Hinshaw, Samuel J H; Ogbeifun, Osato; Wandu, Wambui S et al. (2016) Digoxin Inhibits Induction of Experimental Autoimmune Uveitis in Mice, but Causes Severe Retinal Degeneration. Invest Ophthalmol Vis Sci 57:1441-7
Sun, Xun; Park, James H; Gumerson, Jessica et al. (2016) Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations. Proc Natl Acad Sci U S A 113:E2925-34
Ma, Wenxin; Wong, Wai T (2016) Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease. Adv Exp Med Biol 854:73-8
May-Simera, Helen L; Gumerson, Jessica D; Gao, Chun et al. (2016) Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina. Cell Rep 17:1399-1413
Wang, Yujuan; Hanus, Jakub W; Abu-Asab, Mones S et al. (2016) NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration. Int J Mol Sci 17:
Wang, Xu; Zhao, Lian; Zhang, Jun et al. (2016) Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina. J Neurosci 36:2827-42

Showing the most recent 10 out of 139 publications