The Animal MRI Core has performed MRI studies on 9 projects from Oct-2010 to Sept-2011.Currently active projects are listed below. Currently active projects, alphabetically by Principal Investigator: 1. Arai , Andrew, NHLBI protocol H-0176- Rat Myocardial Fibrosis. MRI microimaging of rat heart in experimental and age-related fibrosis, acute MI, and chronic MI. Novel approach to imaging fresh gadolinium-exposed tissue immediately post-mortem with retention of gadolinium distribution in the tissue. Correlation of microimaging cellular level areas of fibrosis to microscopy and histopathology. Fellow Rajiv Sivendran, NHLBI. Publication: Schelbert EB, Circ Cardiovasc Imaging. 2010;3(6):743-52. 2. Bodine, David, NHGRI protocol G-03-5 -Mouse model of Progeria, characterization of function and aorta cross-sectional area measurements in KO and WT animals in a 4-arm treatment trial over one year. Completed imaging in July 2010 and now completing data analysis. Staff Scientist Mike Erdos, NHGRI. Collaborative project, NHGRI and NHLBI, with PIs Nabel E (formerly NHLBI), Cannon R (NHLBI), Bodine D, Collins FS (OD). 3. Boehm, Manfred, NHLBI protocol H-0185R1- Imaging Mouse myocardial wall post-MI pre- and post-gadolinium contrast. Fellows Dan Yang and Abdalla Elagha, NHLBI. 4. Bustin, Michael, NCI protocol LMC-030 - Characterization of cardiac function in HMGN KO and transgenic mouse lines. Fellows Mark Rochman and Takashi Furusawa, NCI. Collaboration with Adelstein, RS (NHLBI). 5. Jeang, Kuan-Teh, NIAID protocol LMM-10 - Cardiac function of sun-1 and lmna KOs. Fellow Janet Chia-Yen Chen, NIAID. Project performed at request of the Mouse Imaging Facility (MIF). 6. Moss, Joel, NHLBI protocol H-0172R1 - Characterization of lung and kidney abnormalities in FPBP-13 male and female KO and WT mice. Fellows Kjetil Ask (now at McMaster University) and Jiro Kato, NHLBI. 7. Sack, Michael, NHLBI protocol H-0222- Anatomic characterization of ACS mice with structural abnormality of the left atrial area. Fellow Jianhua Li, NHLBI. 8. Remaley, Alan, NHLBI - Investigation of 19F imaging and spectroscopy for detection of trafficking of a 19F substituted cholesterol-like molecule (a fluorescent cholesteryl ester analogue), Bodipy-CE;with input into further changes to the molecule to optimize for imaging. NHLBI. Collaborating scientist Alexander Bogdanov, CC, and Gary Griffiths, NHLBI. 9. Segars, James, NICHD protocol 09-004 - Cardiac function in brx gene deletion mouse model. Currently complete and awaiting their next group of mice after modification of the model. Fellow Catharine Guo NICHD. Collaboration with Adelstein, RS (NHLBI).

Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2011
Total Cost
$84,327
Indirect Cost
Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
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Zip Code
Han, Kim; Hassanzadeh, Shahin; Singh, Komudi et al. (2017) Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress. Sci Rep 7:2093
Klover, Peter J; Thangapazham, Rajesh L; Kato, Jiro et al. (2017) Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3. Elife 6:
Lipinski, Michael J; Albelda, M Teresa; Frias, Juan C et al. (2016) Multimodality imaging demonstrates trafficking of liposomes preferentially to ischemic myocardium. Cardiovasc Revasc Med 17:106-12
Furusawa, Takashi; Rochman, Mark; Taher, Leila et al. (2015) Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness. Nat Commun 6:6138
Tian, E; Stevens, Sharon R; Guan, Yu et al. (2015) Galnt1 is required for normal heart valve development and cardiac function. PLoS One 10:e0115861
Beliveau, Pascale; Cheriet, Farida; Anderson, Stasia A et al. (2015) Quantitative assessment of myocardial fibrosis in an age-related rat model by ex vivo late gadolinium enhancement magnetic resonance imaging with histopathological correlation. Comput Biol Med 65:103-13
Wan, Wuzhou; Liu, Qian; Lionakis, Michail S et al. (2015) Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice. Cardiovasc Res 106:478-87
Holmström, Kira M; Pan, Xin; Liu, Julia C et al. (2015) Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter. J Mol Cell Cardiol 85:178-82
Song, Minjung; San, Hong; Anderson, Stasia A et al. (2014) Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria. Stem Cell Res Ther 5:41
Wen, Han; Gomella, Andrew A; Patel, Ajay et al. (2013) Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings. Nat Commun 4:2659

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