Abstract

The primary goal is to develop new treatments for childhood leukemias and lymphomas. The following projects are currently underway or in preparation: 1) Anti-CD22 Immunotoxins for Treatment of Leukemias and Lymphomas in Childhood 2) Pilot Study of Non-Myeloablative, HLA-Matched Allogeneic Stem Cell Transplantation in Pediatric Leukemias and Lymphomas 3) Unconjugated Monoclonal Antibodies for Treatment Lymphomas In Childhood 4) EPOCH-Rituximab for HIV-Associated Non-Hodgkin's Lymphomas In Childhood 5) Phase II Study of UCN-01 In Relapsed Or Refractory Systemic Anaplastic Large Cell And Mature T-Cell Lymphomas 6) WT1 Peptide-Transduced Allogeneic Dendritic Cell Vaccine for Hematologic Malignancies 7) Hematologic Malignancy Biology Study

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICSC010353-10
Application #
7970173
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2009
Total Cost
$1,159,275
Indirect Cost

  Institution

Name
National Cancer Institute Division of Clinical Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Mehta, Neha; Wayne, Alan S; Kim, Youn H et al. (2012) Bexarotene is active against subcutaneous panniculitis-like T-cell lymphoma in adult and pediatric populations. Clin Lymphoma Myeloma Leuk 12:20-5
Wei, Hui; Xiang, Laiman; Wayne, Alan S et al. (2012) Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy. Proc Natl Acad Sci U S A 109:6898-903
Shah, Nirali N; Bacher, Ulrike; Fry, Terry et al. (2012) Myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation: diagnostic and therapeutic challenges. Am J Hematol 87:916-22
Larochelle, Andre; Gillette, Jennifer M; Desmond, Ronan et al. (2012) Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain. Blood 119:1848-55
Cohen, Jeffrey I; Jaffe, Elaine S; Dale, Janet K et al. (2011) Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States. Blood 117:5835-49
El-Mallawany, N K; Geller, L; Bollard, C M et al. (2011) Long-term remission in a child with refractory EBV(+) hydroa vacciniforme-like T-cell lymphoma through sequential matched EBV(+)-related allogeneic hematopoietic SCT followed by donor-derived EBV-specific cytotoxic T-lymphocyte immunotherapy. Bone Marrow Transplant 46:759-61
Sokolic, Robert; Maric, Irina; Kesserwan, Chimene et al. (2011) Myeloid dysplasia and bone marrow hypocellularity in adenosine deaminase-deficient severe combined immune deficiency. Blood 118:2688-94
Bishop, Michael R; Alyea 3rd, Edwin P; Cairo, Mitchell S et al. (2011) National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee. Biol Blood Marrow Transplant 17:443-54
Zhang, Hua; Cui, Yongzhi; Voong, Nga et al. (2011) Activating signals dominate inhibitory signals in CD137L/IL-15 activated natural killer cells. J Immunother 34:187-95
Jasper, Gregory A; Arun, Indu; Venzon, David et al. (2011) Variables affecting the quantitation of CD22 in neoplastic B cells. Cytometry B Clin Cytom 80:83-90

Showing the most recent 10 out of 28 publications