A number of medical retinal protocols have been conducted at the NEI clinical center. Many are phase 1 studies while others are studies in the screening and evaluation and treatment protocol. These provide patients for screening for trials and epidemiologic studies conducted by the Division of Epidemiology and Clinical Applications. . These include the followup of Age-Related Eye Disease Study, lucentis (anti-VEGF therapy) with high speed indocyanine green angiography for age-related macular degeneration, treatment with microglial inhibitors for diabetic retinopathy and retinovascular occlusions, treatments for central serous retinopathy, and genetic studies of age-related macular degeneration.

National Institute of Health (NIH)
National Eye Institute (NEI)
Clinical Training Intramural Research (ZIE)
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Nicholson, Benjamin P; Nigam, Divya; Toy, Brian et al. (2015) Effect of ranibizumab on high-speed indocyanine green angiography and minimum intensity projection optical coherence tomography findings in neovascular age-related macular degeneration. Retina 35:58-68
Aronow, Mary E; Chew, Emily Y (2014) Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions. Curr Opin Ophthalmol 25:186-90
Chu, Xi K; Meyerle, Catherine B; Liang, Xiaoling et al. (2014) In-depth analyses unveil the association and possible functional involvement of novel RAD51B polymorphisms in age-related macular degeneration. Age (Dordr) 36:9627
Age-Related Eye Disease Study 2 Research Group; Huynh, Nancy; Nicholson, Benjamin P et al. (2014) Visual acuity after cataract surgery in patients with age-related macular degeneration: age-related eye disease study 2 report number 5. Ophthalmology 121:1229-36
Chew, Emily Y; Klein, Michael L; Clemons, Traci E et al. (2014) No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements: AREDS report number 38. Ophthalmology 121:2173-80
Pacak, Karel; Chew, Emily Y; Pappo, Alberto S et al. (2014) Ocular manifestations of hypoxia-inducible factor-2? paraganglioma-somatostatinoma-polycythemia syndrome. Ophthalmology 121:2291-3
Meleth, Annal D; Toy, Brian C; Nigam, Divya et al. (2013) Prevalence and progression of pigment clumping associated with idiopathic macular telangiectasia type 2. Retina 33:762-70
Forooghian, Farzin; Chew, Emily Y; Meyerle, Catherine B et al. (2011) Investigation of the role of neutralizing antibodies against bevacizumab as mediators of tachyphylaxis. Acta Ophthalmol 89:e206-7
Forooghian, Farzin; Stetson, Paul F; Meyer, Scott A et al. (2010) Relationship between photoreceptor outer segment length and visual acuity in diabetic macular edema. Retina 30:63-70
Forooghian, Farzin; Kertes, Peter J; Eng, Kenneth T et al. (2010) Alterations in the intraocular cytokine milieu after intravitreal bevacizumab. Invest Ophthalmol Vis Sci 51:2388-92

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