The CMPB Pathology Core Laboratories have continued to provide critical pathology support services, collaboration and consultation for over 60 research laboratories across the Institute. Over the past year, collaborative and support oriented work has had a significant impact on a spectrum of research programs involved in the study and understanding of a variety of diseases and disease processes such as cardiovascular disease (atherosclerosis), inflammatory respiratory disease, obesity and type II diabetes, inflammatory and immune-mediated renal disease, gene expression and gene regulation, axial skeletal development, cancer and transgenerational effects of diet restriction. The volume and scope of work has increased significantly across all of the Core Laboratories, as have collaborations and consultations with scientific staff whether on a technical level regarding the methods required, or on a scientific level, requiring consultation with a staff pathologist. Core staff have worked with investigators to develop and establish specialized techniques and protocols for a variety of applications. Additionally, using materials from the DNTP subchronic (90-day) and chronic (2-year) bioassays, the Cores have been involved in retrospective studies aimed at elucidating the pathogenesis and molecular mechanisms involved in the development of variety of proliferative non-neoplastic neoplastic lesions.

Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$10,041,552
Indirect Cost
City
State
Country
Zip Code
Edin, Matthew L; Wang, Zhongjing; Bradbury, J Alyce et al. (2011) Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart. FASEB J 25:3436-47
Thomas, Abe C; Nouls, John C; Driehuys, Bastiaan et al. (2011) Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury. Am J Respir Cell Mol Biol 44:648-54
Palmer, Scott M; Flake, Gordon P; Kelly, Fran L et al. (2011) Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. PLoS One 6:e17644
Deng, Yangmei; Edin, Matthew L; Theken, Katherine N et al. (2011) Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice. FASEB J 25:703-13
Adams, E Terence; Auerbach, Scott; Blackshear, Pamela E et al. (2011) Proceedings of the 2010 National Toxicology Program Satellite Symposium. Toxicol Pathol 39:240-66
Lee, Craig R; Imig, John D; Edin, Matthew L et al. (2010) Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. FASEB J 24:3770-81
Witt, Kristine L; Malarkey, David E; Hobbs, Cheryl A et al. (2010) No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environ Mol Mutagen 51:80-8
Crawford, Laura Wilding; Foley, Julie F; Elmore, Susan A (2010) Histology atlas of the developing mouse hepatobiliary system with emphasis on embryonic days 9.5-18.5. Toxicol Pathol 38:872-906
Shim, Minsub; Foley, Julie; Anna, Colleen et al. (2010) Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton. J Biol Chem 285:16206-17
Ghanayem, Burhan I; Bai, Re; Kissling, Grace E et al. (2010) Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. Biol Reprod 82:96-104

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