We interact with NIDA/IRP investigators to develop biomedical informatics applications and solutions that can access, manage, disseminate, and analyze large quantities of high quality data. We develop, research, and/or apply computational tools to assist in the acquisition and analysis of biological, medical behavioral or health data, within a specific time frame determined to be appropriate by the NIDA. We help facilitate new system initiatives and changes to existing systems to meet legislative, regulatory, and departmental requirements within the specific time frames designated by each requirement. We conduct routine system analysis of automatic data processing resources and techniques of existing projects. We recommend, as needed, the implementation of new technologies that are efficient and timely. We provide technical and professional support to help integrate computer systems, design or acquire computer programs, configure and support networks and streamline automated data processing within the NIDA's specified timeframe. We also integrate scientific data systems with network services and security services to foster safe and secure NIDA/IRP laboratory collaboration and for collaboration with extramural entities, when possible integrate scientific data systems with one another and ensure design for interoperable data. We designed and deployed a mobile solution in collaboration with IRP Archway clinic which enables studying craving and mood related to opioid and cocaine use among asymptomatic HCV+ and HCV methadone patients who have not started antiviral treatment. The smartphone-based system is capable of delivering a flexible ecological momentary assessment solution with multi-modal prompting operations as well as having enhanced integrated geolocation recording capabilities dynamically linking craving and mood to the whereabouts of the participants. We also collaborated on a mobile HIV risk reduction intervention to individuals and designed and deployed a video-based smartphone-delivered system combining the capabilities of our mPAL solution with enhanced interactive video-quizzing as an integrated part of our automata-based mobile solution. These systems have been used in multiple protocols and are currently used in studies to better understand why some people are more likely to engage in HIV prevention behaviors. We automate various aspects of clinical and non-clinical programs at the NIDA/IRP. These include but are not limited to functions related to research participant recruiting, pharmacy, nurses, physicians, and other investigators including those at the Johns Hopkins University School of Medicine.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Scientific Computing Intramural Research (ZIH)
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Moran, Landhing M; Kowalczyk, William J; Phillips, Karran A et al. (2018) Sex differences in daily life stress and craving in opioid-dependent patients. Am J Drug Alcohol Abuse 44:512-523
Preston, Kenzie L; Kowalczyk, William J; Phillips, Karran A et al. (2018) Exacerbated Craving in the Presence of Stress and Drug Cues in Drug-Dependent Patients. Neuropsychopharmacology 43:859-867
Kowalczyk, William J; Moran, Landhing M; Bertz, Jeremiah W et al. (2018) Using ecological momentary assessment to examine the relationship between craving and affect with opioid use in a clinical trial of clonidine as an adjunct medication to buprenorphine treatment. Am J Drug Alcohol Abuse 44:502-511
Preston, Kenzie L; Kowalczyk, William J; Phillips, Karran A et al. (2018) Before and after: craving, mood, and background stress in the hours surrounding drug use and stressful events in patients with opioid-use disorder. Psychopharmacology (Berl) 235:2713-2723
Preston, Kenzie L; Kowalczyk, William J; Phillips, Karran A et al. (2017) Context and craving during stressful events in the daily lives of drug-dependent patients. Psychopharmacology (Berl) 234:2631-2642
Furnari, Melody; Epstein, David H; Phillips, Karran A et al. (2015) Some of the people, some of the time: field evidence for associations and dissociations between stress and drug use. Psychopharmacology (Berl) 232:3529-37
Phillips, Karran A; Epstein, David H; Vahabzadeh, Massoud et al. (2014) Substance use and hepatitis C: an ecological momentary assessment study. Health Psychol 33:710-9
Epstein, David H; Tyburski, Matthew; Craig, Ian M et al. (2014) Real-time tracking of neighborhood surroundings and mood in urban drug misusers: application of a new method to study behavior in its geographical context. Drug Alcohol Depend 134:22-29
Phillips, Karran A; Epstein, David H; Mezghanni, Mustapha et al. (2013) Smartphone Delivery of Mobile HIV Risk Reduction Education. AIDS Res Treat 2013:231956
Epstein, David H; Willner-Reid, Jessica; Vahabzadeh, Massoud et al. (2009) Real-time electronic diary reports of cue exposure and mood in the hours before cocaine and heroin craving and use. Arch Gen Psychiatry 66:88-94

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