With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Iowa will acquire a new console and probes for a high field (600 MHz) NMR Spectrometer. This equipment will enable researchers to carry out research on a) investigations of the potential enzymatic role of Zn(II) in myelin basic protein and in the design of chimeric peptides containing Ca(II) or Ln(III) binding sites as a novel DNA binding motif to promote hydrolytic catalysis; b) the discovery, isolation and structural determination of new bioactive natural products; c) structure determination of glycosaminoglycan-derived oligosaccharides; and d) biocatalysis and natural antioxidants. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry and biochemistry.

Agency
National Science Foundation (NSF)
Institute
Division of Chemistry (CHE)
Type
Standard Grant (Standard)
Application #
0235331
Program Officer
Wade N. Sisk
Project Start
Project End
Budget Start
2003-05-01
Budget End
2006-04-30
Support Year
Fiscal Year
2002
Total Cost
$284,575
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
City
Iowa City
State
IA
Country
United States
Zip Code
52242