This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).
With this award from the Major Research Instrumentation (MRI) program Professor Christopher D. Spilling and colleagues from the Chemistry and Biochemistry Department at the University of Missouri-Saint Louis will acquire a 600 MHz NMR spectrometer. The instrument will be used to support research activities dealing with synthetic chemistry as well as structures and dynamics of protein, DNA and other biological macromolecules. Specific examples are: 1) restriction endonuclease structure and function; 2) structure, dynamics and function of PA-binding domains of PP2C-like ABI1 and Raf-like CTR1 in free and lipid-bound forms; 3) structure and conformations of Puf repeat domain-mRNA complexes and mRNA degradation; 4) structure and biological activity of the amyloid-beta peptide; 5) antiviral compounds for HPVs; 6) accelerating iron release from serum transferring; 7) synthetic channels, capsules, and nanotubes designed for transport and for drug delivery; 8) synthesis, mechanism of formation, structure, and conformation of complex glycostructures; 9) application of chiral, non-racemic allylic hydroxy phosphonates for the synthesis of complex natural products; and 10) Pt-Si aggregates from Si-H bond activation reactions.
Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.
Normal 0 false false false EN-US X-NONE X-NONE A grant entitled "MRI-R2 Acquisition of a 600 MHz NMR (CHE 095960) was awarded on January 14th 2010. After an extensive research into available equipment options and a bidding process, Agilent were awarded the contract for the spectrometer January 18th 2011. Installation of the spectrometer into newly renovated lab space began on October 10th 2011 and was completed and the delivery accepted in February 2012. The renovation of the new 600 MHz NMR Spectrometer laboratory was completed at the end of June 2011 including the purchase and delivery of all supporting equipment. A wall was moved to enclose the space and the room was painted. New electric circuit panel was installed dedicated to the NMR instruments and the high voltage lines were installed in the new room. Supplementary HVAC was added to improve room climate control. Compressed air and a nitrogen generator were also been added. The new Agilent DD2 600 MHz spectrometer is based on the Agilent premium COMPACT magnet (54mm bore) and operated by a Linux PC with VnmrJ 3.2 software. Two probes are available. The first is a 5-mm three channel inverse gradient broadband probe [1H-19F/15N-31P, 15N/13C 5mm PFG triple OneNMR probe] and other is a 5-mm gradient broadband probe [1H-19F/15N-31P 5mm PFG autoX indirect detection probe]. Each probe is capable of variable temperature experiments (-80 to +130oC). This spectrometer is a research-oriented instrument and primarily used to investigate the structures and dynamics of macromolecules and complex molecular systems as well as implement new NMR experiments for users in different research areas. The Agilent DD2 600 MHz spectrometer is currently supporting research projects in complex carbohydrate synthesis, antiviral polyamides, natural product synthesis and natural product isolation and structure elucidation. In addition, the spectrometer is used to educate students and postdoctoral associates and provide support to industry in the St. Louis region.
