This award provides funds to the University of Nebraska for funding of a facility that provides advanced mass spectrometric techniques through collaborations with researchers at Nebraska and at other institutions. One of several approaches to mass spectrometry (MS), tandem MS provides high resolution measurements of compounds with the high molecular weights typical of proteins, nucleic acids and other biopolymers. Efforts sponsored by this award will focus on improving techniques for analysis of variety of proteins, carbohydrates and other natural products using the tandem instrument; a variety of collaborative research projects will be initiated or continued, and training activities at the pre- and post doctoral level will continue. Mass spectrometry plays an increasingly important role in the structural analysis of biomolecules. Information about protein sequence and structure, including naturally occurring modifications of proteins, and similar kinds of information about polysaccharides and other branched chain polymers are obtained with great difficulty by other techniques. Because of the considerable expense of acquisition and operation of tandem MS instruments, this type of mass spectrometric analysis is not routinely available at most research institutions. The Nebraska facility is one of only several in the country that provide researchers at numerous institutions with access to the kind of skilled mass spectrometry needed in many areas of modern biological research.

Agency
National Science Foundation (NSF)
Institute
Division of Biological Infrastructure (DBI)
Type
Standard Grant (Standard)
Application #
9017262
Program Officer
Gerald Selzer
Project Start
Project End
Budget Start
1991-05-15
Budget End
1994-04-30
Support Year
Fiscal Year
1990
Total Cost
$513,977
Indirect Cost
Name
University of Nebraska-Lincoln
Department
Type
DUNS #
City
Lincoln
State
NE
Country
United States
Zip Code
68588