Project Report

My projected involved modifying a specific type of polymer to make it biocompatiable for drug delivery purposes. PEDOT is not considered a biocompatible polymer. For in vivo purposes, the intrinsic electronic properties of PEDOT breaks down as scar tissue and other biological impedences interfer with the polymer backbone, therefore the majority of it's uses remain in the energy, electronic, or industrial field. The goal of the project was to modify PEDOT with a biocompatible polymer in order to expand it's usage into biorelated fields. I sucessfully synthesized PEDOT nanotubes and modified them with Polydopamine. Polydopamine is secreted by mussels as they are clinging to rocks or other hard surfaces. The polymer is biocompatible and can be a scaffold for additional modifications. The modification to PEDOT was successful, bringing new in vivo applications to this field of chemistry, expanding the use of conductive polymers beyond energy and industry and into biotechnology. In addition to modifying PEDOT with polydopamine, we incorporated Dox, a well established cancer drug, into polydopamine. This technique is currently being further explored infor controlled drug delivery. We hope the knowledge gained from our promising results can lead directly to controlled in vivo drug delivery vechicles for tumor targeting or neurological diseases.

Agency
National Science Foundation (NSF)
Institute
Office of International and Integrative Activities (IIA)
Application #
1107283
Program Officer
Carter Kimsey
Project Start
Project End
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
Fiscal Year
2011
Total Cost
$5,700
Indirect Cost
Name
Nguyen Thao M
Department
Type
DUNS #
City
Berwyn Heights
State
MD
Country
United States
Zip Code
20740