Pregnant women and children are the groups most susceptible to malaria, which directly kills 1 million children each year. Pregnancy malaria accounts for a large proportion of low birth weight deliveries in endemic areas, and therefore indirectly contributes to an untold number of additional deaths during infancy. Our broad objective is to establish a center of excellence in Tanzania to focus on malaria of pregnant women and children, with an emphasis on research and intervention. This proposal is submitted in conjunction with an application for a Global Network Research Unit Award that will support studies of malaria at the mother-child interface.
Our specific aims i n this proposal will be: 1) establish the technical base within Tanzania to support maternal and early childhood biomedical research;2) provide training at the medical technologist, MSc, PhD, and postdoctoral levels in tropical health and maternal/child health;3) institute a yearly workshop for students, scientists and clinicians from the East African region that will focus on malaria in pregnant women and children, with an emphasis on drug treatment, research ethics, and recent scientific advances. We intend to develop facilities and scientific expertise within the Tanzanian center that will allow future collaborative research on maternal and child health issues, both regional and international. We anticipate that this center will become an important regional asset for scientific networking, formulation of public health policy regarding prophylaxis and treatment of women and children, and a site for interventional studies, including research into behavioral measures (eg, breastfeeding) and vaccines that may reduce malaria morbidity and mortality in these vulnerable populations.

National Institute of Health (NIH)
Fogarty International Center (FIC)
International Research Training Grants (D43)
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Special Emphasis Panel (ZRG1-ICP2-B (51))
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Sina, Barbara J
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Seattle Biomedical Research Institute
United States
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Harrington, Whitney E; Kanaan, Sami B; Muehlenbachs, Atis et al. (2017) Maternal Microchimerism Predicts Increased Infection but Decreased Disease due to Plasmodium falciparum During Early Childhood. J Infect Dis 215:1445-1451
Brickley, E B; Kabyemela, E; Kurtis, J D et al. (2017) Developing a novel risk prediction model for severe malarial anemia. Glob Health Epidemiol Genom 2:e14
Brickley, Elizabeth B; Spottiswoode, Natasha; Kabyemela, Edward et al. (2016) Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study. Am J Trop Med Hyg 95:817-826
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Brickley, Elizabeth B; Wood, Angela M; Kabyemela, Edward et al. (2015) Fetal origins of malarial disease: cord blood cytokines as risk markers for pediatric severe malarial anemia. J Infect Dis 211:436-44
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Kabyemela, Edward; Gonçalves, Bronner P; Prevots, D Rebecca et al. (2013) Cytokine profiles at birth predict malaria severity during infancy. PLoS One 8:e77214
Harrington, Whitney E; Morrison, Robert; Fried, Michal et al. (2013) Intermittent preventive treatment in pregnant women is associated with increased risk of severe malaria in their offspring. PLoS One 8:e56183
Gwamaka, Moses; Fried, Michal; Domingo, Gonzalo et al. (2011) Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia. Malar J 10:386
Harrington, Whitney E; Mutabingwa, Theonest K; Kabyemela, Edward et al. (2011) Intermittent treatment to prevent pregnancy malaria does not confer benefit in an area of widespread drug resistance. Clin Infect Dis 53:224-30

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