The overall objective of this Global Infectious Disease Training Program is to increase research capacity to identify, evaluate and implement strategies to interrupt the transmission and pathogenesis of leishmaniasis and other vector-borne and emerging infectious diseases in Colombia and the Latin American Region. The Training Program builds upon and empowers existing national and regional post graduate programs in biomedical and health science through a portfolio of training modalities and emphasizes the use of communication technologies to sustainably articulate the strengths of national and regional institutions, and connect them with scientific leaders in Yale University and other international institutions. This strategy together with mentored research training, faculty and student exchange, and the development and dissemination of innovative training tools that enable access to research skill building, will address critical gaps in research capacity in infectious disease, and the translation of research results to practice and policy. In response to evolving training needs and opportunities, this application will strategically extend ongoing training in translational research to innovative biotechnological strategies and community based diagnosis, surveillance and management of diseases relevant to Colombia. New areas of research include clinical study design and evaluation and implementation of mobile health strategies and technologies. This will be accomplished through inter- institutional networks and the integration of training in research skills and international elective courses into the curricula of national an regional post graduate programs in biomedical and health sciences. Web-based courses with real-time conferencing of lectures effectively bring together faculty (Yale, national, and international) and students in a dynamic forum for inter-institutional learning and sharing of international expertise. Faculty will participate in mentoring students, research collaboration, developing course content and workshops to strengthen a broad range of research skills. Onsite training in Colombia and the region will be coordinated and driven by Colombian scientists and students, thereby promoting implementation and sustainability of innovative learning strategies by the participating institutions. Specifically the program aims are: 1) To strengthen translationa research training capacity and the clinical application and implementation of research findings by CIDEIM, and the network of national and regional post graduate biomedical sciences programs. 2) To integrate clinical research design and evaluation capacity into multidisciplinary intervention strategies for leishmaniasis, vector-borne and emerging infectious diseases. 3) To strengthen capacity to utilize information & communication technologies in support of research and research training programs, particularly for research in underserved communities. 4) To expand the outreach of web based postgraduate courses and research skill building workshops and tutorials within national programs in biomedical science and health and to institutions in the region.
Transmissible diseases take a high toll in the quality of life of Colombians and neighboring countries. Research capacity to reduce the impact of these diseases is limited by the ability to train a critical mass of doctoral level investigators; Colomban universities have doctoral programs yet these produce few graduates compared to advanced developing countries in Latin American. Our GID training program seeks to strengthen research capacity in infectious disease in Colombia and neighboring countries by building upon and articulating post-graduate programs in biomedical science through of web-based elective graduate level courses, seminars and laboratory-based training in basic, translational and clinical research on leishmaniasis and emerging infectious diseases of public health importance to Colombia and Latin America.
|Gallego-Marin, Carolina; Schrum, Jacob E; Andrade, Warrison A et al. (2018) Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria. J Immunol 200:768-774|
|Correa, Adriana; Del Campo, Rosa; Escandón-Vargas, Kevin et al. (2018) Distinct Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii from Colombian Hospitals. Microb Drug Resist 24:48-54|
|Kip, Anke E; Castro, María Del Mar; Gomez, Maria Adelaida et al. (2018) Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure-response relationships. J Antimicrob Chemother 73:2104-2111|
|Mera-Ramírez, Angélica; Castillo, Andrés; Orobio, Yenifer et al. (2017) Screening of TNF?, IL-10 and TLR4 single nucleotide polymorphisms in individuals with asymptomatic and chronic cutaneous leishmaniasis in Colombia: a pilot study. BMC Infect Dis 17:177|
|Motoa, Gabriel; Muñoz, Juan Sebastián; Oñate, José et al. (2017) Epidemiology of Candida isolates from Intensive Care Units in Colombia from 2010 to 2013. Rev Iberoam Micol 34:17-22|
|Barrera, Maria Claudia; Rojas, Laura Jimena; Weiss, Austin et al. (2017) Profiling gene expression of antimony response genes in Leishmania (Viannia) panamensis and infected macrophages and its relationship with drug susceptibility. Acta Trop 176:355-363|
|Castro, Maria Del Mar; Cossio, Alexandra; Velasco, Carlos et al. (2017) Risk factors for therapeutic failure to meglumine antimoniate and miltefosine in adults and children with cutaneous leishmaniasis in Colombia: A cohort study. PLoS Negl Trop Dis 11:e0005515|
|Martínez-Valencia, Alvaro J; Daza-Rivera, Carlos Frisherald; Rosales-Chilama, Mariana et al. (2017) Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis. PLoS Negl Trop Dis 11:e0005713|
|Berger, Brandon A; Cossio, Alexandra; Saravia, Nancy Gore et al. (2017) Cost-effectiveness of meglumine antimoniate versus miltefosine caregiver DOT for the treatment of pediatric cutaneous leishmaniasis. PLoS Negl Trop Dis 11:e0005459|
|Castro, María Del Mar; Gomez, Maria Adelaida; Kip, Anke E et al. (2017) Pharmacokinetics of Miltefosine in Children and Adults with Cutaneous Leishmaniasis. Antimicrob Agents Chemother 61:|
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