It is clear from work in Caenorhabditis elegans, Drosophila and vertebrates that LIM homeobox (Lhx) genes play pivotal roles in neuronal differentiation. The overall goal of this proposal is to gain insight into the function of Lhx genes using a genetic screen designed to identify targets of the lim-6 transcription factor in C. elegans. The experimental design makes use of the experimental advantages of C.elegans that include genetic amenability, its well-characterized nervous system, and its completed genome sequence. These studies are likely to dissect genes required for function of a defined GABAergic neuronal circuit as well as illuminate the process of neurite sprouting. A complete elucidation of the molecular events underlying neurite sprouting has great promise to provide an understanding of how Lhx genes are linked to this process. It is also worthwhile to note that understanding the molecular basis of neurite sprouting is an important goal given its occurrence in several pathological states such as Alzheimer's disease, epilepsy, and other neurodegenerative conditions. Thus, this approach is highly likely to uncover details of central importance to understanding neural differentiation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32NS011144-01
Application #
6293982
Study Section
Special Emphasis Panel (ZRG1-MDCN-1 (01))
Program Officer
Finkelstein, Robert
Project Start
2000-09-30
Project End
Budget Start
2000-09-30
Budget End
2001-09-29
Support Year
1
Fiscal Year
2000
Total Cost
$32,416
Indirect Cost
Name
Columbia University (N.Y.)
Department
Biochemistry
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032