The objective of the Infectious Diseases and Immunology Project (IDIP) is to coordinate and facilitate the research on emerging infectious agents and the problems they present to the population of the El Paso-Ciudad Juarez region. The high rate of infections with HIV, the incidence of drug-resistant tuberculosis and a growing concern about parasitic infections are examples but not a full spectrum of diseases and their etiologies being investigated. As a common thread, BBRC researchers are studying disease causing viruses and protozoa and investigating basic mechanisms of immunity in attempts to improve disease counter measures. For example, being studied are target molecules of microbes and immune reactions stimulated by them that might guide drug development, lead to a better understanding of pathogenesis, or translate into new diagnostics and vaccines. The IDIP has historically provided strong, well coordinated support, through BBRC Core Laboratories, for its primary researchers and other investigators, and will continue to do so.
New specific Aims to be achieved during this newly requested RCMI funding cycle to enhance research productivity and capacity are to (1) To enhance our research capabilities on border-related infectious diseases using RCMI Supported Facilities and by promoting internal and external collaborations;(2) To promote faculty development by selecting the investigators for funding via the proposed BBRC Pilot Grant Initiatives, and (3) To strengthen the project by recruiting two new faculty members who will complement and extend current research efforts. Expansion of IDIP activities is also occurring through collaborations with investigators at the University of Texas School of Public Health Regional Campus in El Paso, the Texas Tech Health Science Center in El. Paso, and with other UTEP research groups. Related investigations carried out in association with the IDIP all require BBRC Core Laboratories for execution. Funds are being requested to provide administrative supplies and support for IDIP leadership to continue the coordination of these research activities and to offset travel costs of investigators to attend national meetings where they will present their discoveries.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR008124-18
Application #
8357075
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
18
Fiscal Year
2011
Total Cost
$40,540
Indirect Cost
Name
University of Texas El Paso
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
132051285
City
El Paso
State
TX
Country
United States
Zip Code
79968
Cox, Marc B; Johnson, Jill L (2018) Evidence for Hsp90 Co-chaperones in Regulating Hsp90 Function and Promoting Client Protein Folding. Methods Mol Biol 1709:397-422
Contreras, Lisett; Calderon, Ruben I; Varela-Ramirez, Armando et al. (2018) Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones. Cell Oncol (Dordr) 41:623-636
Portillo, Frank; Branch, William R; Conradie, Werner et al. (2018) Phylogeny and biogeography of the African burrowing snake subfamily Aparallactinae (Squamata: Lamprophiidae). Mol Phylogenet Evol 127:288-303
Del Rio, Michelle; Alvarez, Juan; Mayorga, Tania et al. (2017) A comparison of arsenic exposure in young children and home water arsenic in two rural West Texas communities. BMC Public Health 17:850
Sobin, Christina; Flores-Montoya, Mayra Gisel; Alvarez, Juan Manuel (2017) Early chronic low-level Pb exposure alters global exploratory behaviors but does not impair spatial and object memory retrieval in an object-in-place task in pre-adolescent C57BL/6J mice. Neurotoxicol Teratol 61:104-114
Aranda, Gissel P; Hinojos, Samantha J; Sabandal, Paul R et al. (2017) Behavioral Sensitization to the Disinhibition Effect of Ethanol Requires the Dopamine/Ecdysone Receptor in Drosophila. Front Syst Neurosci 11:56
Montoya, Alexa; Amaya, Clarissa N; Belmont, Andres et al. (2017) Use of non-selective ?-blockers is associated with decreased tumor proliferative indices in early stage breast cancer. Oncotarget 8:6446-6460
Iniguez, Eva; Schocker, Nathaniel S; Subramaniam, Krishanthi et al. (2017) An ?-Gal-containing neoglycoprotein-based vaccine partially protects against murine cutaneous leishmaniasis caused by Leishmania major. PLoS Negl Trop Dis 11:e0006039
Zimkus, Breda M; Lawson, Lucinda P; Barej, Michael F et al. (2017) Leapfrogging into new territory: How Mascarene ridged frogs diversified across Africa and Madagascar to maintain their ecological niche. Mol Phylogenet Evol 106:254-269
Dai, Liping; Peng, Xuan-Xian; Tan, Eng M et al. (2016) Tumor-associated antigen CAPER? and microvessel density in hepatocellular carcinoma. Oncotarget 7:16985-95

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