Basic science VA investigators at our facility require the use of super-resolution confocal microscopy for their research programs. The requested equipment will upgrade the excitation, detection and software of our existing Leica SP5 core confocal laser scanning microscope (purchased in 2011 with ShEEP funds) to a super-resolution instrument that will be used to support VA research at the Central Texas Veterans Health Care System (CTVHCS). This upgrade will allow investigators to more effectively perform macro and micro imaging of live and fixed cells, tissues and small organisms outlined in their VA and NIH funded research programs. This system will enhance the capability of our research center to better understanding of underlying mechanisms responsible for the pathological conditions that lead to significant mortality and morbidity in the Veteran population.

Public Health Relevance

Cells and tissues that model various pathological processes have played a vital part in medical breakthroughs in the past decade that have benefited the health care of Veterans. The super-resolution imaging equipment requested in this application will be used to study intracellular signaling and protein interactions under pathological conditions that lead to significant mortality and morbidity in the Veteran population. Results of this proposed research will provide a better understanding of underlying mechanisms critical for designing new therapies for the prevention and treatment of these diseases.

Agency
National Institute of Health (NIH)
Institute
Veterans Affairs (VA)
Type
Veterans Administration (IS1)
Project #
1IS1BX004407-01
Application #
9575346
Study Section
Special Initiatives - Shared Equipment (ShEEP/LAMb) (SPLJ)
Project Start
2018-01-01
Project End
2018-09-30
Budget Start
2018-01-01
Budget End
2018-09-30
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Olin Teague Veterans Center
Department
Type
DUNS #
029847394
City
Temple
State
TX
Country
United States
Zip Code
76504