Dr. Suman's long-term career goals and interests are to understand the mechanism(s) by which adaptations occur in the cardiovascular, pulmonary and skeletal muscle systems in response to exercise. Broadly, he foresees himself establishing a scientific investigative career in physiology and using exercise as an interventional tool against functional disability and disease. His immediate career goals involve investigating the adaptations to exercise that occur in severely burned children. Currently, Dr. Suman proposes to continue his research at the University of Texas Medical Branch and Shriners Hospitals for Children, in collaboration with Dr. David N. Herndon, Dr. Robert R. Wolfe and Dr. Daniel L. Traber. Research: The physiological response to a severe burn injury includes a persistent and extensive skeletal muscle catabolism and weakness that leads to a low physical capacity. In non-burn individuals, exercise training induces adaptations that include improvement of cardiovascular (CV) and muscle function. However, whether exercise confers these adaptions in burned children in currently unknown. A better understanding of the adaptations to exercise training is important and relevant in burns, where alterations in cardiovascular and muscle function are major obstacles in the return to physical activities of daily living. The proposed study will test the hypothesis that exercise, in severely burned children, will improve CV and muscle performance by increasing cardiac function, oxygen uptake and utilization, and skeletal muscle mass.
Specific Aim 1 will assess whether decreases in CV and skeletal muscle function in severely burned children are due to compromised cardiac performance and skeletal muscle oxidative function and decreased concentration of myosin heavy chain.
Specific Aim 2 will assess whether the compromised level of CV and muscle function will be improved with exercise training.
Specific Aim 3 will assess whether administration of an anabolic agent (oxandrolone) to burned children will further enhance the effects of exercise on CV and skeletal muscle functional capacity. We expect these Specific Aims to serve as a springboard for future studies in the treatment and long-term rehabilitation of burned children.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01HL070451-02
Application #
6627728
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F3))
Program Officer
Schucker, Beth
Project Start
2002-04-02
Project End
2007-03-31
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
2
Fiscal Year
2003
Total Cost
$125,093
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Surgery
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Malagaris, Ioannis; Herndon, David N; Polychronopoulou, Efstathia et al. (2018) Determinants of skeletal muscle protein turnover following severe burn trauma in children. Clin Nutr :
Rivas, Eric; Herndon, David N; Chapa, Martha L et al. (2018) Children with severe burns display no sex differences in exercise capacity at hospital discharge or adaptation after exercise rehabilitation training. Burns 44:1187-1194
Rivas, Eric; McEntire, Serina J; Herndon, David N et al. (2018) Resting ?-Adrenergic Blockade Does Not Alter Exercise Thermoregulation in Children With Burn Injury: A Randomized Control Trial. J Burn Care Res 39:402-412
Gauglitz, Gerd G; Toliver-Kinsky, Tracy E; Williams, Felicia N et al. (2010) Insulin increases resistance to burn wound infection-associated sepsis. Crit Care Med 38:202-8
Jeschke, Marc G; Kraft, Robert; Emdad, Fatemeh et al. (2010) Glucose control in severely thermally injured pediatric patients: what glucose range should be the target? Ann Surg 252:521-7; discussion 527-8
McEntire, Serina J; Chinkes, David L; Herndon, David N et al. (2010) Temperature responses in severely burned children during exercise in a hot environment. J Burn Care Res 31:624-30
Jeschke, Marc G; Kulp, Gabriela A; Kraft, Robert et al. (2010) Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial. Am J Respir Crit Care Med 182:351-9
McEntire, Serina J; Lee, Jong O; Herndon, David N et al. (2009) Absence of exertional hyperthermia in a 17-year-old boy with severe burns. J Burn Care Res 30:752-5
Neugebauer, Christine Tuden; Serghiou, Michael; Herndon, David N et al. (2008) Effects of a 12-week rehabilitation program with music &exercise groups on range of motion in young children with severe burns. J Burn Care Res 29:939-48
Alloju, Shashi M; Herndon, David N; McEntire, Serina J et al. (2008) Assessment of muscle function in severely burned children. Burns 34:452-9

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