This revised application for competing continuation of an Independent Scientist Award (K02) entitled """"""""Monoarninergic Function in Geriatric Neuropsychiatry"""""""" outlines a career development plan to further enhance the candidate's research and the scope of her mentorship activities as she has done over the past five years. The candidate's research career has focused on the development and application of methods that has integrated Positron Emission Tomography (PET) imaging of glucose metabolism and neuroreceptors with pharmacologic interventions to evaluate monoaminergic function in vivo. The candidate has conducted her research and training activities by collaborating with senior investigators in interventions and neurobiologic research in schizophrenia, Alzheimer's disease (AD) and geriatric depression. These collaborations have enabled her to pursue the overarching theme of her funded research that decreased monoaminergic responsiveness is related to pathophysiology and thus, to the response to pharmacotherapy across these disorders. She has accomplished the primary goal of the initial award period of integrating neurochemical brain imaging studies into clinical trials. The primary research focus of the past five years was the development and application of in vivo methods to evaluate serotonergic function and modulation by other neurotransmitters (dopamine, acetylcholine) in neuropsychiatric disorders. The research and training activities conducted in the next five years will focus on 1) the completion of several funded projects to evaluate serotonin function in schizophrenia, Alzheimer's Disease and geriatric depression, 2) the initiation of mechanistic and intervention studies in these disorders that focus on further elucidating serotonin and dopamine function and 3) training in the areas of neuropharmacology, preclinical, postmortem and in vivo imaging of monoaminergic systems. The long-term goal of the candidate's research is to understand the pathophysiology of treatment response variability in neuropsychiatric disorders of the elderly by developing and applying neuropharmacologic imaging methods. The Independent Scientist Award will enable the candidate to continue to firmly focus her research and mentorship activities in the area of geriatric neuropsychiatry.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH001621-10
Application #
7198138
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Evans, Jovier D
Project Start
1998-08-01
Project End
2009-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
10
Fiscal Year
2007
Total Cost
$124,416
Indirect Cost
Name
Feinstein Institute for Medical Research
Department
Type
DUNS #
110565913
City
Manhasset
State
NY
Country
United States
Zip Code
11030
Marano, Christopher M; Workman, Clifford I; Lyman, Christopher H et al. (2015) Structural imaging in late-life depression: association with mood and cognitive responses to antidepressant treatment. Am J Geriatr Psychiatry 23:4-12
Sankar, Tejas; Chakravarty, M Mallar; Bescos, Agustin et al. (2015) Deep Brain Stimulation Influences Brain Structure in Alzheimer's Disease. Brain Stimul 8:645-54
Hirao, Kentaro; Smith, Gwenn S (2014) Positron emission tomography molecular imaging in late-life depression. J Geriatr Psychiatry Neurol 27:13-23
Marano, Christopher M; Workman, Clifford I; Lyman, Christopher H et al. (2014) The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging. Psychiatry Res 222:84-90
Marano, Christopher M; Workman, Clifford I; Kramer, Elisse et al. (2013) Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging. Int J Geriatr Psychiatry 28:417-23
Smith, Gwenn S; Laxton, Adrian W; Tang-Wai, David F et al. (2012) Increased cerebral metabolism after 1 year of deep brain stimulation in Alzheimer disease. Arch Neurol 69:1141-8
Munro, Cynthia A; Workman, Clifford I; Kramer, Elisse et al. (2012) Serotonin modulation of cerebral glucose metabolism: sex and age effects. Synapse 66:955-64
Diaconescu, Andreea Oliviana; Kramer, Elisse; Hermann, Carol et al. (2011) Distinct functional networks associated with improvement of affective symptoms and cognitive function during citalopram treatment in geriatric depression. Hum Brain Mapp 32:1677-91
Gunning, Faith M; Smith, Gwenn S (2011) Functional neuroimaging in geriatric depression. Psychiatr Clin North Am 34:403-22, viii
Smith, Gwenn S; Workman, Clifford I; Kramer, Elisse et al. (2011) The relationship between the acute cerebral metabolic response to citalopram and chronic citalopram treatment outcome. Am J Geriatr Psychiatry 19:53-63

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