Abstract

This application for an RSA requests support to complete two related projects. The first is the Danish high risk for schizophenia study; this is a prospective study of children of schizophenic mothers. The are at high risk of becoming schizophrenic. They were examined in 1962, 1967, and 1972. A follow-up is now planned for 1986 when they will average 39 years. Data analyses to date suggest that genetic predisposition for schizophrenia interacts wit environmental insult (perinatal and early childhood trauma) to increase the probability of schizophrenic breakdown. The 1986 follow-up will enable us to test the reliability of these findings. The perinatal data relate to adult CT scan-detected-brain anomalies. Data from other laboratories and from the HR study suggest the possible role of fetal viral infection in the perinatal difficulties. An ongoing population study in Finland is described in which adult psychopathological outcomes are being related to viral infections contracted during pregnancy. Positive preliminary findings in this study have encouraged plans to continue this line of work.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Award (K05)
Project #
5K05MH000619-04
Application #
3075804
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1986-07-15
Project End
1991-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90033

  Publications

Venables, Peter H; Liu, Jianghong; Raine, Adrian et al. (2007) Prenatal influenza exposure and delivery complications: implications for the development of schizophrenia. Fam Community Health 30:151-9
Schiffman, Jason; Maeda, Justin A; Hayashi, Kentaro et al. (2006) Premorbid childhood ocular alignment abnormalities and adult schizophrenia-spectrum disorder. Schizophr Res 81:253-60
Schiffman, Jason; Pestle, Sarah; Mednick, Sara et al. (2005) Childhood laterality and adult schizophrenia spectrum disorders: a prospective investigation. Schizophr Res 72:151-60
Schiffman, Jason; Lam, Cecilia W; Jiwatram, Tina et al. (2004) Perspective-taking deficits in people with schizophrenia spectrum disorders: a prospective investigation. Psychol Med 34:1581-6
Schiffman, Jason; Walker, Elaine; Ekstrom, Morten et al. (2004) Childhood videotaped social and neuromotor precursors of schizophrenia: a prospective investigation. Am J Psychiatry 161:2021-7
Liu, Jianghong; Raine, Adrian; Venables, Peter H et al. (2004) Malnutrition at age 3 years and externalizing behavior problems at ages 8, 11, and 17 years. Am J Psychiatry 161:2005-13
Raine, Adrian; Mellingen, Kjetil; Liu, Jianghong et al. (2003) Effects of environmental enrichment at ages 3-5 years on schizotypal personality and antisocial behavior at ages 17 and 23 years. Am J Psychiatry 160:1627-35
Liu, Jianghong; Raine, Adrian; Venables, Peter H et al. (2003) Malnutrition at age 3 years and lower cognitive ability at age 11 years: independence from psychosocial adversity. Arch Pediatr Adolesc Med 157:593-600
Schiffman, Jason; Ekstrom, Morten; LaBrie, Joseph et al. (2002) Minor physical anomalies and schizophrenia spectrum disorders: a prospective investigation. Am J Psychiatry 159:238-43
Raine, Adrian; Venables, Peter H; Mednick, Sarnoff et al. (2002) Increased psychophysiological arousal and orienting at ages 3 and 11 years in persistently schizotypal adults. Schizophr Res 54:77-85

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