Atrial fibrillation is the most common cause of clinically significant sustained tachycardia and occurs in up to 12% of individuals that are over age 75. Incidence increases with each decade of life. Furthermore, atrial fibrillation is responsible for up to 1/3 of thromboembolic strokes. The selection of available antiarrhythmic drugs and their efficacy is limited. Accordingly, there is an important need for the development of new antiarrhythmic agents that are safe in patients with structural heart disease and are absence of significant negative chronotropic effects. One such drug is Azimilide dihydrochloride, a class III antiarrhythmic agent with very weak bradycardic effects at test doses. This study is to test the long-term safety and efficacy of this new antiarrhythmic drug.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
2000
Total Cost
$81,814
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
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