This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Despite widespread concern about obesity and related health risks in persons with spinal cord injury (SCI), limited weight loss interventional research has been conducted in this patient population; we know little about whether the same health benefits could be achieved by weight loss or the potential adverse effects of inappropriate weight loss on compromising lean body mass and general health. This randomized controlled trial is conducted to assess the feasibility and initial effectiveness of a structured 12-week home-based weight loss program, covering nutrition, exercise, and behavior modification, among persons with SCI who are overweight or obese. Participants are randomly assigned to one of two groups: 1) 12 weekly video and telephone intervention and 2) usual care (one-time dietary counseling). Primary outcome measure of body weight and secondary outcomes, including body composition measured by dual energy x-ray absorptiometry and waist and neck circumference, will be examined at baseline and immediately after intervention. The controlled clinical and laboratory conditions and well-trained personnel provided by the GCRC outpatient support and bionutrition services will enhance the quality of this study and potentially facilitate the recruitment and retention of study subjects. If shown to be effective, through an affordable and accessible home-based weight loss program, individuals with SCI worldwide can benefit with a healthier lifestyle, prevention of obesity-related diseases, and improvement in independent functioning and social participation.
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