To compare two different routes of intermittently administered rhIL-2 with a highly active antiretroviral regimen to highly active antiretroviral therapy alone with respect to the proportion of subjects achieving 50% increase in CD4 counts above prerandomization baseline values after one year of rhIL-2 and the rate of change in CD4 counts. To compare the safety tolerance and effect on quality of life of these regimens. To assess the effects of rhIL-2 with highly active antiretroviral therapy on changes in immune cell phenotypes and function and on HIV viral load and rate of antiviral drung resistance development.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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