This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The measurement of AB metabolism in humans is important due to the pathologic relationship between AB and Alzheimer's Disease. Better understanding of AB metabolism in humans may lead to improved understanding of the pathogenesis of the disease, earlier diagnosis, and a way to evaluate treatments.
The aim of this experiment is to determine if the pathogenic AB peptide in humans can be labeled using a stable isotope amino acid. The approach will be to label AT in vivo, collect and isolate the labeled and unlabeled AB, quantitate the percent of unlabeled AB, and to determine the reproducibility and reliability of the measurements.
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