This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This long-term observational study continues to examine complications of type 1 diabetes. It examines factors associated with development of kidney, macrovascular, eye and nerve complications of diabetes. Study volunteers first participated in the Diabetes Control and Complications Trial (DCCT), between 1984 and 1993. Visits occur annually, for laboratory and physical assessment. Eye exams, scans for cardiac and circulatory status, and evaluations of cognitive skills are included on an intermittent basis. Over the next two years, more detailed assessments of neurological function will be completed. Numerous articles have been published so far. Notably, this study has introduced a concept called 'metabolic memory' as a possible explanation for differences in the appearance and progression of diabetes complications that are still evident between the original conventional and intensive treatment groups, despite years of nearly equal glucose control since DCCT completion. In an allied study, we obtained DNA, blood and urine chemistry, blood pressure, and body size data from 139 first-degree relatives of the University of Washington DCCT/EDIC subjects. This is being analyzed along with samples collected from relatives at other EDIC clinics. Most of the relatives were seen on the GCRC, but others participated through phone interview and 'remote' lab tests at their local physicians' offices. Data is being studied to see what DNA commonalities, if any, appear among family groups where the DCCT/EDIC subject does or does not have significant complications of diabetes. The relatives were seen on the GCRC between September 2002 and August of 2004
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