This is a Phase I trial designed to evaluate infusional phosphorothioate c-myb antisense oligodeoxynucleotide (LR3001) in CML. The objectives of this study are to evaluate the toxicity of LR3001 in patients with CML in accelerated phase or blast crisis and to evaluate the pharmacokinetics of LR-3001 when supporting laboratory studies with any toxicities and clinical responses observed.

Project Start
1997-03-17
Project End
1998-02-28
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
37
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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