This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Epidemiology of Diabetes Intervention and Complications (EDIC) study is an ongoing observation of nearly 1400 people with type 1 diabetes, who were also involved in the Diabetes Control and Complications Trial (DCCT). The DCCT showed that tight control of blood sugar levels delayed the start, or slowed the progress of complications that often affect the eyes, kidneys and nerves of people with type 1 diabetes. The main purpose of the EDIC is to learn more about heart and blood vessel disease in people with type 1 diabetes. In the EDIC, former DCCT participants are seen every year for a variety of tests that measure the function of the heart and blood vessels and to look for signs of heart and blood vessel disease (that can result in heart attacks or strokes). Tests are also done to measure blood sugar control, and to measure the current status of complications of eye, kidney and nerve damage, to better understand the long-term effects of tight blood glucose control achieved in the DCCT.
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