The main objective of this five year study is to determine the low-dose-response range of Norwalk virus (NV) infectivity, and to define a dose-response curve for Snow Mountain virus. Snow Mountain virus is a related virus causing the same acute gastroenteritis as Norwalk. Norwalk virus is the leading cause of epidemic viral gastroenteritis in older children and adults int eh United States. It is typically found in drinking water, recreational water, ice, shellfish, various food items and environmental contaminations. It is likely that a significant portion of """"""""acute gastrointestinal illness of unknown etiology"""""""" episodes are related to Norwalk virus, and that Norwalk and related viruses may be responsible for up to 23% of the waterborne outbreaks of acute gastroenteritis.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000046-39S2
Application #
6263842
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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