This is a medical research study for patients with Crohn's disease intended to investigate the safety and therapeutic effect of two different doses of an antibody (a protein) against TNF compared to a placebo (inactive substance). The name of the antibody is Infliximab (Remicade). Infliximab has been developed to decrease the effects of TNF and to reduce the inflammation and ulceration of the bowel. Infliximab is a chimeric antibody which means the antibody is part mouse protein and part human protein. The goal of the study is to evaluate whether patients respond longer.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000046-40
Application #
6414061
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1974-10-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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