A patient with hypertiglyceridemia with elevated apo C-III that inactivates lipoprotein lipase and interferes with apo-E receptor-mediated uptake of remnant particles by the liver has been identified, providing a unique opportunity to study the nature of the biochemical defect and the contribution of apo C-III to the pathophysiology of hyperlipidemia, to assess the effect of lipid-lowering diets on the properties of apo C-III and to study the genetics of this disorder.

Project Start
Project End
Budget Start
Budget End
Support Year
29
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
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