This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. COPD stands for Chronic Obstructive Pulmonary Disease. COPD is a term that refers mainly to two closely related respiratory disorders that gradually take a person's breath away: chronic bronchitis and/or emphysema associated with airflow obstruction. The primary symptom of COPD is shortness of breath accompanied by a cough or wheezing. There is no cure for COPD, only treatment to ease the symptoms of this disease. However, researchers are not clear how this disease occurs. The easiest way to obtain researchable information is to take a broncoalveolar lavage (BAL) and or endobronchial biopsy sample since they contain cells, proteins (combination of amino acids that make-up cells) and other factors. A BAL sample is fluid produced by the lungs mixed with sterile (free from germs that cause infection) salt water. An endobronchial biopsy sample is a piece of lung tissue the size of a breadcrumb taken from the larger, closer air passages. The purpose of this study is to evaluate the blood and airway of subjects with mild to moderate COPD while undergoing standard treatment to better assess how these standard therapies work.
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