This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol is primarily an epidemiological study of type 1 diabetes and its complications with particular emphasis on macrovascular disease. The EDIC is designed as a long-term follow-up of participants in the Diabetes Control and Complications Trial (DCCT). The DCCT, which was completed in 1994, was a well known prospective randomized trial of 1,441 subjects randomized to intense versus conventional glycemic control. The results provided compelling evidence of the benefit of glycemic control towards preventing microvascular and neurological complications. The EDIC now offers an opportunity for continued prospective follow-up of this large group of subjects, thus promising new data on the occurrence, pathogenesis, risk factors and treatments of diabetic complications. The EDIC also takes advantage of prior intention-to-treat analysis based on previous involvement of the study population in the DCCT. In addition, the EDIC facilitates the study of macrovascular disease in type 1 diabetes, an issue that the DCCT could not adequately address over the 5-9 year participation of the relatively young subjects (13-39 years old at enrollment in the DCCT). The EDIC also incorporates a genetic component involving family members of participants in order to learn more about the contribution of genes to the development and progression of the long-term complications of type 1 diabetes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000059-45
Application #
7377096
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-03-01
Project End
2007-02-28
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
45
Fiscal Year
2006
Total Cost
$23,823
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Choo-Wosoba, Hyoyoung; Gaskins, Jeremy; Levy, Steven et al. (2018) A Bayesian approach for analyzing zero-inflated clustered count data with dispersion. Stat Med 37:801-812
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Curtis, A M; Cavanaugh, J E; Levy, S M et al. (2018) Examining caries aetiology in adolescence with structural equation modelling. Community Dent Oral Epidemiol 46:258-264
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Kwon, Soyang; Janz, Kathleen F; Letuchy, Elena M et al. (2017) Association between body mass index percentile trajectories in infancy and adiposity in childhood and early adulthood. Obesity (Silver Spring) 25:166-171
Warren, John J; Van Buren, John M; Levy, Steven M et al. (2017) Dental caries clusters among adolescents. Community Dent Oral Epidemiol 45:538-544

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