This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Patients with chronic renal failure (CRF) are prone to develop malnutrition which is associated with increased morbidity and mortality. Malnutrition could result from either impaired eating or excessive catabolism. We will assess appetite, measure food consumption and at the same time quantitate catabolism by measuring metabolic rate and urinary urea nitrogen excretion. Simultaneously, we will measure a number of hormones known to be related to eating and energy expenditure. The perturbation to be introduced in this study will include 40 hours of fasting and 24 hours of re-feeding. Four groups of study subjects will be included (1) CRF patients on hemodialysis, (2) CRF patients not yet on dialysis, (3) renal transplant subjects and (4) normal controls. The hormones to be studied are divided into two categories, those that have a circadian rhythm and those that are meal-related. The former includes leptin, neuropeptide Y and alpha melanocyte-stimulating hormone, and the latter, cholecystokinin, ghrelin and peptide YY. All the measurements will be done in baseline state, during a 40-hour fast and a 24-hour re-feeding. Overall nutritional status of the subjects will be assessed using DEXA scan, anthropometry and subjective global assessment score. Appetite will be assessed by the visual analogue scale.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000059-46
Application #
7604881
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-03-01
Project End
2007-09-16
Budget Start
2007-03-01
Budget End
2007-09-16
Support Year
46
Fiscal Year
2007
Total Cost
$10,312
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
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