This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Disruptive Behavior Disorders are a group of childhood-onset psychiatric conditions characterized by externalizing behaviors such as impulsivity, verbal and physical aggression, and delinquency (collectively referred to as conduct problems). Aripiprazole is a new atypical antipsychotic with a partial dopamine (D2) receptor agonist activity. This study will collect clinical measures of impulsivity, delinquency, and aggression as well as brain structural MRI scans obtained at baseline and at the end of the study. These investigators expect to find a correlation between baseline grey matter volume of ventral prefrontal cortices and severity of aggression. Furthermore, they hypothesize that clinical improvement in aggressive behavior will be strongly correlated with a reduction in attention deficit hyperactivity disorder symptomatology in children taking aripiprazole. Finally, they predict the presence of an association between clinical improvement and changes in ventral prefrontal volumetric measures.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000059-46
Application #
7604899
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-03-01
Project End
2007-09-16
Budget Start
2007-03-01
Budget End
2007-09-16
Support Year
46
Fiscal Year
2007
Total Cost
$137
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
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