This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Among disorders of the nervous system, a large number of conditions exist in which individuals suffer the acute onset of transient neurologic symptoms. Dr. Swoboda is studying a group of inherited neurologic disorders in which abnormal movements constitute the main neurologic symptoms. These abnormal movements are called dyskinesias. Pedigree studies are done to identify affected family members, then gene loci are identified via linkage analysis. She then uses either a candidate gene analysis approach or positional cloning approach to identify a specific candidate gene of interest. Dr. Swoboda hypothesizes that a number of genes will be involved in such disorders, and is actively working on defining gene candidates in three such disorders: paroxysmal kinesigenic dyskinesia, paroxysmal nonkinesigenic dyskinesia, and alternating hemiplegia of childhood. This study utilizes the GCRC outpatient clinic, the core laboratories, and the pediatric neurology clinic at the Primary Childrens Medical Center, connected to the University Hospital by a bridge.
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