This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Little is known about the time course of the EAA in humans. Therefore the purpose of the project is to support our ongoing interests in muscle protein metabolism and nutrition using a blend of EAA.
Specific Aims and Procedures: We hypothesize that energy expenditure will be higher in younger healthy adults compared to the water control. We will measure resting energy expenditure in young healthy adults using a computer that measures the rate of oxygen consumed and carbon dioxide produced at rest. Upon arriving the subject will be consented and vital signs and weight and height will be obtained. The subject will take 15 grams of protein and have two separate 2-hour blocks of breathing under a bubble separated by a convenience break in which the subject will either go to the bathroom or stretch to reduce positional cramps or stiffness. Following a brief break, another two hour block of gas measurements will be measured. Following this test a body composition test will be measured using a low level x-ray machine (DEXA). Significance: The appeal of this study is that with a limited number of calories it might be possible to increase energy expenditures in persons who are infirmed and or those who have limited exercise capacity.
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