Blacks are at increased risk for noninsulin dependent diabetes mellitus (NIDDM), obesity, cardiovascular disease and hypertension. A common pathogenetic link among these entities could be hyperinsulinemia/insulin resistance. The goal of this project is to test the hypothesis that black children, compared with their white counterparts, have an inherent reduction in insulin action.
Specific aims are 1a) to determine whether or not black children are more insulin resistant than white children independent of family history of NIDDM. 1b) To quantitate the earliest impairments in glucose and fat metabolism by a cross-sectional study of prepubertal black vs white children, and pubertal black vs white adolescents. 1c) To evaluate the impact of physical activity/fitness on insulin sensitivity in black vs white children. 2a) To determine if for the same degree of obesity (total and abdominal) black children are more insulin resistant than white children. 2b) To assess if during an intravenous intralipid challenge, black adolescents are more likely than whites to store rather than combust the fat load.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
38
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Children's Hosp Pittsburgh/Upmc Health Sys
Department
Type
DUNS #
044304145
City
Pittsburgh
State
PA
Country
United States
Zip Code
15224
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